Protein Information

Name glutathione S transferase
Synonyms GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2…

Compound Information

Name zineb
CAS

Reference List

PubMed Abstract RScore(About this table)
8295852 Nebbia C, Dacasto M, Soffietti MG, Rasero R, Principato GB, Di Simplicio P: Inhibition of hepatic xenobiotic metabolism and of glutathione-dependent enzyme activities by zinc ethylene-bis-dithiocarbamate in the rabbit. Pharmacol Toxicol. 1993 Oct;73(4):233-9.

It is concluded that (1) zineb is able to selectively impair oxidative drug metabolism with possible different mechanism (s) according to the duration of the exposure, (2) only the subchronic treatment affects glutathione-dependent enzymes, (3) the decrease in glutathione S-transferase activity would seem to be ascribed to a direct interaction with the fungicide.
88(1,1,2,3) Details
8516783 Siddiqui A, Ali B, Srivastava SP: Effect of mancozeb on hepatic glutathione S-transferase in rat. Toxicol Lett. 1993 Jun;68(3):301-5.

2(0,0,0,2) Details
8509224 Hasegawa R, Cabral R, Hoshiya T, Hakoi K, Ogiso T, Boonyaphiphat P, Shirai T, Ito N: Carcinogenic potential of some pesticides in a medium-term multi-organ bioassay in rats. Int J Cancer. 1993 May 28;54(3):489-93.


The number of glutathione S-transferase placental-form-positive liver-cell foci was significantly increased in the captan- and phosmet-treated groups.
1(0,0,0,1) Details
9801766 Fabra A, Angelini J, Donolo A, Permigiani M, Castro S: Biochemical alterations in Bradyrhizobium sp USDA 3187 induced by the fungicide Mancozeb. Antonie Van Leeuwenhoek. 1998 Apr;73(3):223-8.


In order to elucidate the fungicide toxicity mechanism we determined the effects of Mancozeb on cell chemical composition, glutathione (GSH) content (molecule involved in the detoxification process), glutathione S-transferase (GST) activity and on polyamine, exopolysaccharides, capsular polysaccharides and lipopolysaccharides.
1(0,0,0,1) Details