Protein Information

Name hemoglobin (protein family or complex)
Synonyms Hemoglobin; Hemoglobins

Compound Information

Name endosulfan
CAS 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin 3-oxide

Reference List

PubMed Abstract RScore(About this table)
7900959 Naqvi SM, Vaishnavi C: Bioaccumulative potential and toxicity of endosulfan insecticide to non-target animals. Comp Biochem Physiol C. 1993 Jul;105(3):347-61.

Endosulfan I (a metabolite) causes a significant change in norepinephrine, 5-HT and GABA. (b) Renal toxicity: inhibition of MFOs activity was noticed in rats; other effects included changes in proximal convoluted tubules and necrosis of the tubular epithelium. (c) Hepatotoxicity: chemically-induced aminopyrine N-demethylase and aniline hydrolase were found in rat liver, and reduction in the glycogen level occurred. (d) Hematologic toxicity: endosulfan exposure resulted in a significant decrease in the level occurred. (d) Hematologic toxicity: endosulfan exposure resulted in a significant decrease in the erythrocyte glutathione reductase, hemoglobin amount, RBC number and mean corpuscular volume. 4.
31(0,1,1,1) Details
10509431 Akay MT, Ozmen G, Elcuman EA: Effects of combinations of endosulfan, dimethoate and carbaryl on immune and hematological parameters of rats. Vet Hum Toxicol. 1999 Oct;41(5):296-9.

IgG and IgM levels and hematological parameters (red and white blood cell counts, thrombocyte, monocyte, lymphocyte and granulocyte counts and hemoglobin concentrations) were determined in albino rats exposed to combinations of endosulfan, dimethoate and carbaryl.
6(0,0,1,1) Details
20020928 Hatipoglu FS, Gulay MS, Balic A, Yildiz-Gulay O, Volkan S: Subacute oral toxicity of endosulfan in male new zealand white rabbits. Toxicol Mech Methods. 2008 Jan;18(9):705-10.

Alterations recorded in hematological parameters within the groups (hemoglobin, packed cell volume, and total erythrocyte count) were due to endosulfan exposure.
6(0,0,1,1) Details
16624371 Lee SM, Lee SB, Park CH, Choi J: Expression of heat shock protein and hemoglobin genes in Chironomus tentans (Diptera, chironomidae) larvae exposed to various environmental pollutants: a potential biomarker of freshwater monitoring. Chemosphere. 2006 Nov;65(6):1074-81. Epub 2006 Apr 19.

As pollutants, we examined nonylphenol, bisphenol-A, 17alpha-ethynyl estradiol, bis (2-ethylhexyl) phthalate, endosulfan, paraquat dichloride, chloropyriphos, fenitrothion, cadmium chloride, lead nitrate, potassium dichromate, benzo [a] pyrene and carbon tetrachloride.
3(0,0,0,3) Details
18443843 Aggarwal M, Naraharisetti SB, Sarkar SN, Rao GS, Degen GH, Malik JK: Effects of subchronic coexposure to arsenic and endosulfan on the erythrocytes of broiler chickens: a biochemical study. Arch Environ Contam Toxicol. 2009 Jan;56(1):139-48. Epub 2008 Apr 29.

At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.
1(0,0,0,1) Details
18292956 Giron-Perez MI, Montes-Lopez M, Garcia-Ramirez LA, Romero-Banuelos CA, Robledo-Marenco ML: Effect of sub-lethal concentrations of endosulfan on phagocytic and hematological parameters in Nile tilapia (Oreochromis niloticus). Bull Environ Contam Toxicol. 2008 Mar;80(3):266-9. Epub 2008 Feb 22.

0(0,0,0,0) Details