| Name | Adenosine A2A receptor |
|---|---|
| Synonyms | ADORA 2; ADORA2; ADORA2A; Adenosine A2 receptor; Adenosine A2a receptor; RDC 8; RDC8; hA2aR… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15771443 | Vu CB, Pan D, Peng B, Kumaravel G, Smits G, Jin X, Phadke D, Engber T, Huang C, Reilly J, Tam S, Grant D, Hetu G, Petter RC: Novel diamino derivatives of [1,2,4] triazolo [1,5-a][1,3,5] triazine as potent and selective adenosine A2a receptor antagonists. J Med Chem. 2005 Mar 24;48(6):2009-18. Piperazine derivatives of 2-furanyl [1,2,4] triazolo [1,5-a][1,3,5] triazine have recently been demonstrated to be potent and selective A (2a) receptor antagonists with oral activity in rodent models of Parkinson's disease. |
1(0,0,0,1) | Details |
| 15341933 | Vu CB, Pan D, Peng B, Sha L, Kumaravel G, Jin X, Phadke D, Engber T, Huang C, Reilly J, Tam S, Petter RC: Studies on adenosine A2a receptor antagonists: comparison of three core heterocycles. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4831-4. Piperazine and (R)-2-(aminomethyl) pyrrolidine derivatives of [1,2,4] triazolo [1,5-a][1,3,5] triazine have recently been shown to be potent and selective A (2a) receptor antagonists. |
1(0,0,0,1) | Details |
| 15341934 | Vu CB, Shields P, Peng B, Kumaravel G, Jin X, Phadke D, Wang J, Engber T, Ayyub E, Petter RC: Triamino derivatives of triazolotriazine and triazolopyrimidine as adenosine A2a receptor antagonists. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4835-8. Piperazine derivatives of 2-furanyl [1,2,4] triazolo [1,5-a][1,3,5] triazine have recently been shown to be potent and selective A (2a) receptor antagonists. |
1(0,0,0,1) | Details |
| 15294001 | Vu CB, Peng B, Kumaravel G, Smits G, Jin X, Phadke D, Engber T, Huang C, Reilly J, Tam S, Grant D, Hetu G, Chen L, Zhang J, Petter RC: Piperazine derivatives of [1,2,4] triazolo [1,5-a][1,3,5] triazine as potent and selective adenosine A2a receptor antagonists. J Med Chem. 2004 Aug 12;47(17):4291-9. |
32(0,1,1,2) | Details |
| 15566292 | Peng H, Kumaravel G, Yao G, Sha L, Wang J, Van Vlijmen H, Bohnert T, Huang C, Vu CB, Ensinger CL, Chang H, Engber TM, Whalley ET, Petter RC: Novel bicyclic piperazine derivatives of triazolotriazine and triazolopyrimidines as highly potent and selective adenosine A2A receptor antagonists. J Med Chem. 2004 Dec 2;47(25):6218-29. |
31(0,1,1,1) | Details |
| 17236762 | Neustadt BR, Hao J, Lindo N, Greenlee WJ, Stamford AW, Tulshian D, Ongini E, Hunter J, Monopoli A, Bertorelli R, Foster C, Arik L, Lachowicz J, Ng K, Feng KI: Potent, selective, and orally active adenosine A2A receptor antagonists: arylpiperazine derivatives of pyrazolo [4,3-e]-1,2,4-triazolo [1,5-c] pyrimidines. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1376-80. Epub 2006 Dec 3. |
2(0,0,0,2) | Details |