| Name | thrombin |
|---|---|
| Synonyms | Coagulation factor II; Coagulation factor II variant; F2; F2 protein; F2 protein precursor; Factor II; PT; Prothrombin… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15189031 | Alexopoulos K, Fatseas P, Melissari E, Vlahakos D, Roumelioti P, Mavromoustakos T, Mihailescu S, Paredes-Carbajal MC, Mascher D, Matsoukas J: Design and synthesis of novel biologically active thrombin receptor non-peptide mimetics based on the pharmacophoric cluster /Arg/NH2 of the Ser42----Arg46 motif sequence: platelet aggregation and relaxant activities. J Med Chem. 2004 Jun 17;47(13):3338-52. The identification of the thrombin receptor has promoted the interest for the development of new therapeutic agents capable of selectively inhibiting unwanted biological effects of thrombin on various cell types. N-(6-Guanidohexanoyl)-N'-(phenylacetyl) piperazine (1), N-(phenylacetyl)-4-(6-guanidohexanoylamidomethyl) piperidine (2), and N-(phenylacetyl)-3-(6-guanidohexanoylamido) pyrrolidine (3) (group A) carry the two pharmacophoric side chains of and Arg residues incorporated on three different templates (piperazine, 4-aminomethylpiperidine, and 3-aminopyrrolidine). |
3(0,0,0,3) | Details |
| 11824472 | Maragoudakis ME, Kraniti N, Giannopoulou E, Alexopoulos K, Matsoukas J: Modulation of angiogenesis and progelatinase a by thrombin receptor mimetics and antagonists. Endothelium. 2001;8(3):195-205. FPR and the piperazine derivatives caused suppression of angiogenesis and in combination with thrombin antagonized its angiogenic effect. |
85(1,1,1,5) | Details |
| 16390138 | Radi AE, Acero Sanchez JL, Baldrich E, O'Sullivan CK: Reagentless, reusable, ultrasensitive electrochemical molecular beacon aptasensor. J Am Chem Soc. 2006 Jan 11;128(1):117-24. A bifunctional derivative of the thrombin-binding aptamer with a redox-active Fc moiety and a thiol group at the termini of the aptamer strand was synthesized. The modified electrode showed a voltammetric signal due to a one-step redox reaction of the surface-confined ferrocenyl moiety of the aptamer immobilized on the electrode surface in 10 mM N-(2-hydroxyethyl) piperazine-N'-2-ethanesulfonic acid (HEPES) buffer of pH 8.0. |
4(0,0,0,4) | Details |
| 11498991 | Zhu FM, Wen ZB, He XF, Li JC, He SL: [Expression of tissue factor of astrocytes and its signal transductional pathways]. Sheng Li Xue Bao. 1999 Jun;51(3):291-6. The aim of this study was to observe the expression of tissue factor (TF) of astrocytes in basic culture medium and under the condition stimulated by thrombin and to explore the relevant signal transduction pathways. The results showed that 4-bromo ionophore (A23187) and phorbol 12- 13- (PMA) enhanced significantly the TF expression of astrocytes, but the expression was decreased markedly by trifluoperazine (TFP) and 1-(5-isoquinolinyl sulfonyl)-3-methyl-piperazine (H7) in the basic medium. |
3(0,0,0,3) | Details |
| 15456260 | Haginoya N, Kobayashi S, Komoriya S, Yoshino T, Suzuki M, Shimada T, Watanabe K, Hirokawa Y, Furugori T, Nagahara T: Synthesis and conformational analysis of a non-amidine factor Xa inhibitor that incorporates 5-methyl-4,5,6,7-tetrahydrothiazolo [5,4-c] as S4 binding element. J Med Chem. 2004 Oct 7;47(21):5167-82. Among this series, 5-methyl-4,5,6,7-tetrahydrothiazolo [5,4-c] type 61 displayed orally potent anti-fXa activity and evident prolongation of prothrombin time (PT) with the moderate bioavailability in rats. |
1(0,0,0,1) | Details |