| Name | 5 HT1D |
|---|---|
| Synonyms | 5 HT 1D; 5 HT 1D alpha; 5 HT1D; 5 hydroxytryptamine (serotonin) receptor 1D; 5 hydroxytryptamine 1D receptor; HT1DA; HTR1D; HTR1DA… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11216445 | Villalon CM, Centurion D, Sanchez-Lopez A, De Vries P, Saxena P: receptors mediating external carotid vasoconstriction in vagosympathectomized dogs. Zhongguo Yao Li Xue Bao. 1999 Dec;20(12):1057-67. With the advent of subtype-selective antagonists it was subsequently shown that external carotid vasoconstriction to and is dose-dependently antagonized by the selective 5-HT1B receptor antagonist SB224289 (2,3,6,7-tetrahydro-1'-methyl-5-[2'-methyl-4' (5-methyl-1,2,4-oxadiazol-3-yl) biphenyl-4-carbonyl] furo [2,3-f] -3-spiro-4'-piperidine hydrochloride), whereas the selective 5-HT1D receptor antagonist BRL15572 (1-(3-chlorophenyl)-4-[3,3-diphenyl (2-(S,R) hydroxypropanyl) piperazine] hydrochloride) was ineffective. |
32(0,1,1,2) | Details |
| 14744615 | Villalon CM, Centurion D, Willems EW, Arulmani U, Saxena PR, Valdivia LF: 5-HT1B receptors and alpha 2A/2C-adrenoceptors mediate external carotid vasoconstriction to dihydroergotamine. Eur J Pharmacol. 2004 Jan 26;484(2-3):287-90. This response was: (1) partly blocked in dogs pretreated intravenously with the antagonists SB224289 (5-HT (1B); 2,3,6,7-tetrahydro-1'-methyl-5-[2'-methyl-4' (5-methyl-1,2,4-oxadiazol-3-yl) biphenyl-4-carbonyl] furo [2,3-f] -3-spi ro-4'-piperidine hydrochloride), rauwolscine (alpha (2)), BRL44408 (alpha (2A); 2-[2H-(1-methyl-1,3-dihydroisoindole) methyl]-4,5-dihydroimidazole) or MK912 (alpha (2C); (2S,12bS)-1'3'-dimethylspiro (1,3,4,5',6,6',7,12b-octahydro-2Hbenzo [b] furo [ 2,3-a] quinazoline)-2,4'-pyrimidin-2'-one); (2) markedly blocked after SB224289 plus rauwolscine; and (3) unaffected after BRL15572 (5-HT (1D); 1-(3-chlorophenyl)-4-[3,3-diphenyl (2-(S,R) hydroxypropanyl) piperazine] hydrochloride) or imiloxan (alpha (2B)). |
31(0,1,1,1) | Details |
| 16173953 | Calama E, Ortiz de Urbina AV, Moran A, Martin ML, San Roman L: Effect of on neurogenic vasoconstriction in the isolated, autoperfused hindquarters of the rat. Clin Exp Pharmacol Physiol. 2005 Oct;32(10):894-900. The effects of were mimicked by 5-carboxamidotryptamine (a 5-HT1 receptor agonist) and L-694 247 (a selective 5-HT1D receptor agonist), but not by 8--2-dipropylaminotetralin (a 5-HT1A receptor agonist), CGS-12066B (a 5-HT1B receptor agonist), alpha-methyl- (a 5-HT2 receptor agonist), 1-(3-chlorophenyl) piperazine (a 5-HT2C receptor agonist) or 1-phenylbiguanide (a 5-HT3 receptor agonist). The selective 5-HT1D/1B receptor antagonist BRL 15572 inhibited the effect of the agonist L-694 247. 4. |
2(0,0,0,2) | Details |
| 17584957 | Papageorgiou A, Denef C: Stimulation of growth hormone release by in cultured rat anterior pituitary cell aggregates: evidence for mediation by 5-HT2B, 5-HT7, 5-HT1B, and ketanserin-sensitive receptors. Endocrinology. 2007 Sep;148(9):4509-22. Epub 2007 Jun 21. The present data suggest that may release GH through a pituitary site of action, and that the 5-HTR2B, 5-HTR7 and 5-HTR1B mediate this response, with possibly an inhibitory component of the 5-HTR1D. Basal GH release was stimulated by the 5-HTR2 agonists 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, m-chlorophenyl piperazine, and alpha-methyl 5-carboxytryptamine (agonist at 5-HTR1, -5, and -7); (preferential 5-HTR7 agonist); and the selective 5-HTR1B agonist CP93129 but not the 5-HTR1A agonists 7-(dipropylamino) tetralin-1-ol-8--2-(di-n-propylamino) tetralin and the 5-HTR1B/D agonist |
1(0,0,0,1) | Details |
| 11888550 | Millan MJ, Newman-Tancredi A, Lochon S, Touzard M, Aubry S, Audinot V: Specific labelling of 5-HT (1B) receptors in rat frontal cortex with the novel, phenylpiperazine derivative, [3H] GR125,743. Pharmacol Biochem Behav. 2002 Apr;71(4):589-98. These rank orders of affinity correspond to the binding profile of 5-HT (1B) rather than 5-HT (1D) receptors. In competition binding studies, affinities were determined for 15 chemically diverse 5-HT (1B) agonists, including 2-[5-[3-(4-methylsulphonylamino) benzyl-1,2,4-oxadiazol-5-yl]-1H-indole-3-y l] ethylamine (L694,247; pK (i), 10.4), 5-carboxamidotryptamine (5-CT; 9.7), 3-[3-(2-dimethylamino-ethyl)-1H-indol-6-yl]-N-(4-methoxybenzyl) acrylamide (GR46,611; 9.6), 5-methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indole (RU24,969; 9.5), dihydroergotamine (DHE; 8.6), 5-H-pyrrolo [3,2-b] pyridin-5-one,1,4-dihydro-3-(1,2,3,6-tetrahydro-4-pyridi nyl (CP93,129; 8.4), anpirtoline (7.9), (7.4), 1-[2-(3-fluorophenyl) ethyl]-4-[3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl] pro pyl] piperazine (L775,606; 6.4) and (minus sign)-1 (S)-[2-[4-(4-methoxyphenyl) piperazin-1-yl] ethyl]-N-methyl-3,4-dihyd ro-1H-2-benzopyran-6-carboxamide (PNU109,291; <5.0). |
1(0,0,0,1) | Details |
| 15452415 | Calama E, Moran A, Ortiz de Urbina AV, Martin ML, San Roman L: m-CPP, a 5-HT2C receptor agonist that modifies the perfusion pressure of the hindquarter vascular bed of anesthetized rat. Pharmacology. 2005 Feb;73(2):70-5. Epub 2004 Sep 27. Both vasodilatation and vasoconstriction were inhibited by the (1,2 ) receptor antagonist methiothepin, whereas the 5-HT (2 ) receptor antagonist ritanserin blocked only the vasoconstrictor responses. 1-[4-(1-Adamantanecarboxamido) butyl]-4-(2-methoxyphenyl) piperazine (a 5-HT (1A) receptor antagonist) and ICI 118,551 (a beta (2)-receptor antagonist) failed to modify the vasodilator responses of m-CPP. Both BRL 15572 (a 5-HT (1D) receptor antagonist) and GR 55562 (a 5-HT (1B) receptor antagonist) only partially inhibited this action. |
1(0,0,0,1) | Details |
| 15866558 | Tsaltas E, Kontis D, Chrysikakou S, Giannou H, Biba A, Pallidi S, Christodoulou A, Maillis A, Rabavilas A: Reinforced spatial alternation as an animal model of obsessive-compulsive disorder (OCD): investigation of 5-HT2C and 5-HT1D receptor involvement in OCD pathophysiology. Biol Psychiatry. 2005 May 15;57(10):1176-85. |
1(0,0,0,1) | Details |
| 11070185 | Shaw AM, Bunton DC, Brown T, Irvine J, MacDonald A: Regulation of sensitivity to in pulmonary supernumerary but not conventional arteries by a 5-HT (1D)-like receptor. Eur J Pharmacol. 2000 Nov 10;408(1):69-82. Neither the selective 5-HT (1D) receptor antagonist (1-(3-chlorophenyl)-4-[3, 3-diphenyl (2-(S,R) hydroxypropanyl) piperazine] hydrochloride (BRL15572) nor the 5-HT (1B) receptor antagonist (2,3,6, 7-tetrahydro-1'-methyl-5-[2'methyl-4'5-(methyl-1,2,4-oxadiazol-3-y l) biphenyl-4-carbonyl] furo [2,3-f] -3-spiro-4'-piperidine hydrochloride (SB224289) antagonised concentration-response curves induced by or (1)-receptor-selective agonists. |
0(0,0,0,0) | Details |
| 16153839 | Wyman PA, Marshall HR, Flynn ST, King RJ, Thompson M, Smith PW, Hadley MS, Price GW, Scott CM, Dawson LA: Identification of a potent and selective 5-HT1B receptor antagonist. . Bioorg Med Chem Lett. 2005 Nov 1;15(21):4708-12. An SAR study around the mixed 5-HT1ABD receptor antagonist SB-272183 found that introduction of cis-2,6-dimethyl substitution onto the piperazine ring was a key structural change, which imparted a combination of both excellent selectivity over the 5-HT1A and 5-HT1D receptors and low intrinsic activity. |
31(0,1,1,1) | Details |
| 11350497 | Fernandez MM, Calama E, Moran A, Martin ML, San Roman L: Characterization of mechanisms involved in presynaptic inhibition of sympathetic pressor effects induced by some 5-HT1 receptor antagonists. J Auton Pharmacol. 2000 Oct-Dec;20(5-6):313-23. In a previous study, we showed that the presynaptic inhibitory action of 5-hydroxytryptamine receptor agonists on sympathetic pressor effects obtained in the pithed rats were mainly mediated by activation of 5-HT1A and 5-HT1D receptor subtypes. |
1(0,0,0,1) | Details |