| 12951101 |
Letavic MA, Barberia JT, Carty TJ, Hardink JR, Liras J, Lopresti-Morrow LL, Mitchell PG, Noe MC, Reeves LM, Snow SL, Stam EJ, Sweeney FJ, Vaughn ML, Yu CH: Synthesis and biological activity of piperazine-based dual MMP-13 and TNF-alpha converting enzyme inhibitors. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3243-6.
A series of novel MMP-13 and TNF-alpha converting enzyme inhibitors based on piperazine 2-hydroxamic acid scaffolds are described. |
193(2,3,3,3) |
Details |
| 11677139 |
Levin JI, Chen JM, Du MT, Nelson FC, Wehr T, DiJoseph JF, Killar LM, Skala S, Sung A, Sharr MA, Roth CE, Jin G, Cowling R, Di L, Sherman M, Xu ZB, March CJ, Mohler KM, Black RA, Skotnicki JS: The discovery of anthranilic acid-based MMP inhibitors. Bioorg Med Chem Lett. 2001 Nov 19;11(22):2975-8.
Piperazine 4u has been identified as a potent, selective, orally active inhibitor of MMP-9 and MMP-13. |
82(1,1,1,2) |
Details |