| Name | 5 HT 5 |
|---|---|
| Synonyms | 5 Hydroxytryptamine receptor 5A; 5 hydroxytryptamine 5A receptor; 5 HT 5; 5 HT 5A; 5 HT 5A receptor; 5 HT5A; 5 HT5A receptor; 5 hydroxytryptamine (serotonin) receptor 5A… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11448518 | Hasuo H, Akasu T: facilitates spatiotemporal propagation of optical signals in the hippocampal-septal pathway. Neurosci Res. 2001 Jul;40(3):265-72. Bicuculline blocked the -induced facilitation of the optical signal. 8--di-n-propylamino tetralin (8-OH-DPAT), a selective 5-HT (1A) agonist, mimicked the facilitation of 1-(2-Methoxyphenyl)-4-(4-phthalimidobutyl) piperazine (NAN-190), a 5-HT (1A) antagonist, blocked the facilitation induced by 5-HT. 5-HT enhanced the amplitude of the field potential in septal slices, where the optical signals had been enhanced. |
31(0,1,1,1) | Details |
| 15582454 | Chu W, Tu Z, McElveen E, Xu J, Taylor M, Luedtke RR, Mach RH: Synthesis and in vitro binding of N-phenyl piperazine analogs as potential D3 receptor ligands. Bioorg Med Chem. 2005 Jan 3;13(1):77-87. Binding studies were also conducted to determine if the compounds bound to sigma (sigma (1) and sigma (2)) and (5-HT (1A), 5-HT (2A), 5-HT (2B), 5-HT (2C), 5-HT (3), 5-HT (4), 5-HT (5), 5-HT (6), and 5-HT (7)) receptors. |
1(0,0,0,1) | Details |
| 15588097 | Leopoldo M, Berardi F, Colabufo NA, Contino M, Lacivita E, Niso M, Perrone R, Tortorella V: Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents. J Med Chem. 2004 Dec 16;47(26):6616-24. A series of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides was prepared and their affinity for 5-HT) 5-HT7, 5-HT (1A), and 5-HT (2A) receptors was measured by in vitro binding assays. In relation to 5-HT7 receptor affinity, receptor binding studies indicated that (i) the optimal alkyl chain length was five methylenes, (ii) an unsubstituted 1,2,3,4-tetrahydronaphthalenyl nucleus was preferred, and (iii) the substitution pattern of the aryl ring linked to the piperazine ring played a crucial role. |
1(0,0,0,1) | Details |
| 11906967 | Centurion D, Ortiz MI, Saxena PR, Villalon CM: The atypical 5-HT2 receptor mediating tachycardia in pithed rats: pharmacological correlation with the 5-HT2A receptor subtype. Br J Pharmacol. 2002 Mar;135(6):1531-9. In pithed rats, intraperitoneally (i.p.) pre-treated with reserpine (5 mg kg (-1)), intravenous (i.v.) administration of 5-HT, 5- (5-MeO-T), 1-(3-chlorophenyl) piperazine (mCPP) and 5-carboxamidotryptamine (5-CT) (10, 30, 100 and 300 microg kg (-1) each), produced dose-dependent tachycardic responses. |
6(0,0,1,1) | Details |
| 14609542 | van der Vegt BJ, Lieuwes N, Cremers TI, de Boer SF, Koolhaas JM: Cerebrospinal fluid monoamine and metabolite concentrations and aggression in rats. Horm Behav. 2003 Sep;44(3):199-208. In sharp contrast to the hypothesis and our expectation, a clear positive correlation was found between the individual level of trait-like aggressiveness and CSF concentrations of 5-HT, 5-HIAA, (NE), (DA), and 3,4- |
1(0,0,0,1) | Details |
| 16308184 | Frampton AE, Andrews JC, Parfitt A, Jagroop IA, Mikhailidis DP, Henry JA: Does meta-chlorophenylpiperazine (mCPP) activate human platelets? . Platelets. 2006 Feb;17(1):30-6. mCPP (meta-chlorophenylpiperazine), an agonist at 5-HT) 5-HT2 receptors, has been used as a probe of serotonergic function. |
1(0,0,0,1) | Details |
| 19345236 | Lorenzi V, Carpenter RE, Summers CH, Earley RL, Grober MS: social status and sex change in the bluebanded goby Lythrypnus dalli. Physiol Behav. 2009 Jun 22;97(3-4):476-83. Epub 2009 Apr 2. Males and newly sex changed fish showed a trend for higher levels of 5-HIAA and 5-HT/5-HIAA ratio than females. |
1(0,0,0,1) | Details |
| 11489454 | Jeong HJ, Han SH, Min BI, Cho YW: 5-HT1A receptor-mediated activation of G-protein-gated inwardly rectifying K+ current in rat periaqueductal gray neurons. Neuropharmacology. 2001 Aug;41(2):175-85. I5-HT was mimicked by a 5-HT1A receptor selective agonist, 8-OH-DPAT, and was reversibly blocked by a 5-HT1A receptor antagonist, piperazine but not by a 5-HT2 receptor antagonist, ketanserin. |
0(0,0,0,0) | Details |
| 16553644 | Kitazawa T, Ukai H, Komori S, Taneike T: Pharmacological characterization of -induced contraction in the chicken gastrointestinal tract. Auton Autacoid Pharmacol. 2006 Apr;26(2):157-68. The proventriculus (area of stomach adjacent to the oesophagus) and ileum are examined. applied cumulatively caused sustained contraction of the proventriculus that was not decreased by tetrodotoxin, atropine or l-nitro- methylester (l-NAME). alpha-Methyl- showed the same potency as that of indicating the involvement of the 5-HT (2) receptor. (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane (DOI), and 1-(3-chlorophenyl) piperazine hydrochloride (mCPP) were potent, and 2-methyl-5-HT, 5-carboxamidotryptamine, BW723C86 and 6-chloro-2-(1-piperazinyl) pyrazine hydrochloride (MK212) were moderate, but (+/-)-8--2-dipropylaminotetralin hydrobromide (8-OH-DPAT), [endo-N-8-methyl-8-azabicyclo-(3,2,1) oct-3-yl]-2,3-dihydro-(1-methyl) ethyl -2-oxo-1H-benzimidazol-1-carboxamide (BIMU-8) and cisapride were weak agonists. |
0(0,0,0,0) | Details |
| 11557597 | Fu XW, Wang D, Pan J, Farragher SM, Wong V, Cutz E: Neuroepithelial bodies in mammalian lung express functional type 3 receptor. Am J Physiol Lung Cell Mol Physiol. 2001 Oct;281(4):L931-40. Application of the 5-HT (5-150 microM) and 5-HT (3)-R agonist 2-methyl-5-HT (5-150 microM) induced inward currents in a concentration-dependent manner. |
1(0,0,0,1) | Details |
| 15985260 | Jordan S, Chen R, Koprivica V, Hamilton R, Whitehead RE, Tottori K, Kikuchi T: In vitro profile of the antidepressant candidate OPC-14523 at rat and human 5-HT1A receptors. Eur J Pharmacol. 2005 Jul 11;517(3):165-73. This study determined the in vitro functional profile of 1-[3-[4-(3-chlorophenyl)-1-piperazinyl] propyl]-5-methoxy-3,4-dihydro-2-qui nolinone monomethanesulfonate (OPC-14523) at rat and human (5-HT) 5-HT1A receptors and binding affinity of OPC-14523 at human frontocortical 5-HT1A receptors. |
1(0,0,0,1) | Details |
| 18439428 | Takeda H, Sadakane C, Hattori T, Katsurada T, Ohkawara T, Nagai K, Asaka M: Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism. Gastroenterology. 2008 Jun;134(7):2004-13. Epub 2008 Feb 29. METHODS: We investigated the decreases of plasma acylated-ghrelin level and food intake caused by cisplatin, (5-HT), 5-HT agonists, and vagotomy as well as the decrease-suppressing effects of rikkunshito and antagonists. |
1(0,0,0,1) | Details |
| 15589386 | Bandoh T, Hayashi M, Ino K, Takada S, Ushizawa D, Hoshi K: Acute effect of milnacipran on the relationship between the locus coeruleus noradrenergic and dorsal raphe serotonergic neuronal transmitters. Eur Neuropsychopharmacol. 2004 Dec;14(6):471-8. A single administration of milnacipran (60 mg/kg, s.c.) markedly decreased the levels of NA and its metabolite, in the locus coeruleus and the levels of, a metabolite of (5-HT), 5-hydroxyindole-3- (5-HIAA) in the dorsal raphe nucleus. |
1(0,0,0,1) | Details |