| Name | Acetylcholinesterase |
|---|---|
| Synonyms | ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19460190 | Miezan Ezoulin JM, Shao BY, Xia Z, Xie Q, Li J, Cui YY, Wang H, Dong CZ, Zhao YX, Massicot F, Qiu ZB, Heymans F, Chen HZ: Novel piperazine derivative PMS1339 exhibits tri-functional properties and cognitive improvement in mice. Int J Neuropsychopharmacol. 2009 Nov;12(10):1409-19. Epub 2009 May 22. We report herein a novel piperazine derivative compound PMS1339 possesses multifunctional properties including anti-platelet-activating factor, AChE inhibition, Abeta aggregation inhibition and cognitive improvement. |
87(1,1,1,7) | Details |
| 16735118 | Sadashiva CT, Narendra Sharath Chandra JN, Ponnappa KC, Veerabasappa Gowda T, Rangappa KS: Synthesis and efficacy of 1-[bis (4-fluorophenyl)-methyl] piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in Alzheimer's disease. Bioorg Med Chem Lett. 2006 Aug 1;16(15):3932-6. Epub 2006 Jun 2. |
81(1,1,1,1) | Details |
| 17192004 | Jiang X, Ao L, Zhou C, Yang L, Zhang Q, Li H, Sun L, Wu X, Bai H, Zhao Y: Design, synthesis, and biological evaluation of new territrem B analogues. Chem Biodivers. 2005 Apr;2(4):557-67. Some 23 analogues of the potent acetylcholinesterase (AChE) inhibitor territrem B (1) were designed, synthesized, and tested for their biological activities. The two N-atoms of the piperazine moieties in 5o, 5p, and 5r might further enhance the inhibitory effects. |
3(0,0,0,3) | Details |
| 16257398 | Hyatt JL, Tsurkan L, Morton CL, Yoon KJ, Harel M, Brumshtein B, Silman I, Sussman JL, Wadkins RM, Potter PM: Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11. Chem Biol Interact. 2005 Dec 15;157-158:247-52. Epub 2005 Oct 28. Structural analogs of 4-piperidinopiperidine however, did not inhibit AChE, including a benzyl piperazine derivate of CPT-11. |
3(0,0,0,3) | Details |
| 16878490 | Sapronov NS, Fedotova IuO, Losev NA: [Optimizing effect of the combined administration of 8-OH-DPAT and galantamine on depression--anxiety behavior in old rats with dementia of Alzheimer's type]. Eksp Klin Farmakol. 2006 May-Jun;69(3):10-3. The effect of chronic (14 days) administration of the 5-HT (1A) receptors agonist 8-OH-DPAT (0.05 mg/kg, s.c.) and the 5-HT (1A) receptors antagonist -190 (0.1 mg/kg, i.p.) alone or in combination with the acetylcholinesterase inhibitor galantamine (1.0 mg/kg, i.p.) on depression and anxiety was studied in old (24 months) male rats with dementia of Alzheimer's type. |
1(0,0,0,1) | Details |
| 15146031 | Millan MJ, Gobert A, Roux S, Porsolt R, Meneses A, Carli M, Di Cara B, Jaffard R, Rivet JM, Lestage P, Mocaer E, Peglion JL, Dekeyne A: The serotonin1A receptor partial agonist S15535 [4-(benzodioxan-5-yl) 1-(indan-2-yl) piperazine] enhances cholinergic transmission and cognitive function in rodents: a combined neurochemical and behavioral analysis. J Pharmacol Exp Ther. 2004 Oct;311(1):190-203. Epub 2004 May 14. In the absence of acetylcholinesterase inhibitors, S15535 dose-dependently (0.04-5.0 mg/kg s.c.) elevated dialysis levels of in the frontal cortex and dorsal hippocampus of freely moving rats. |
1(0,0,0,1) | Details |