| 17027138 |
Zunkler BJ, Claassen S, Wos-Maganga M, Rustenbeck I, Holzgrabe U: Effects of fluoroquinolones on HERG channels and on pancreatic beta-cell ATP-sensitive K+ channels. Toxicology. 2006 Dec 7;228(2-3):239-48. Epub 2006 Sep 8.
Four newly synthesized fluoroquinolone derivatives with either a p-fluoro-phenyl (compound C3) or an o-fluoro-phenyl (compound C4) substituent at position N (1) and an additional dimethylated piperazine ring (compounds C1 and C2) inhibited HERG currents by 7.3-14.7% at test concentrations of 100 microM. |
85(1,1,1,5) |
Details |