| Name | NK 1 |
|---|---|
| Synonyms | B3GAT1; CD57; CD57 antigen; GLCATP; Galactosylgalactosylxylosylprotein 3 beta glucuronosyltransferase 1; GlcAT I; GlcAT P; GlcUAT P… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12372532 | Ryckmans T, Berton O, Grimee R, Kogej T, Lamberty Y, Pasau P, Talaga P, Genicot C: Dual NK (1) antagonists-- reuptake inhibitors as potential antidepressants. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3195-8. The synthesis, structure-affinity relationship and activity of benzyloxyphenethyl piperazine derivatives combining NK (1) antagonism and reuptake inhibition is described. |
82(1,1,1,2) | Details |
| 15982585 | Gao M, Mock BH, Hutchins GD, Zheng QH: Synthesis and initial PET imaging of new potential NK1 receptor radioligands 1-[2-(3,5-bis-trifluoromethyl-benzyloxy)-1-phenyl-ethyl]-4-[11C] methyl-pip erazine and {4-[2-(3,5-bis-trifluoromethyl-benzyloxy)-1-phenyl-ethyl]-piperazine-1-yl} - [11C] methyl ester. Nucl Med Biol. 2005 Jul;32(5):543-52. The NK (1) receptor radioligands 1-[2-(3,5-bis-trifluoromethyl-benzyloxy)-1-phenyl-ethyl]-4-[(11) C] methyl-p iperazine ([(11) C] BMP, [(11) C]) and {4-[2-(3,5-bis-trifluoromethyl-benzyloxy)-1-phenyl-ethyl]-piperazine-1-yl} - [(11) C] methyl ester ([(11) C] BME, [(11) C]) were synthesized for evaluation as new potential PET imaging agents for brain NK (1) receptors. |
81(1,1,1,1) | Details |
| 12372524 | Blythin DJ, Chen X, Piwinski JJ, Shih NY, Shue HJ, Anthes JC, McPhail AT: Synthesis and NK (1)/NK (2) binding activities of a series of diacyl-substituted 2-arylpiperazines. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3161-5. X-ray crystallographic analysis of the crystalline di-BOC derivative of the NK (2) active piperazine (15) showed that the 2R configuration was associated with NK (2) activity. |
4(0,0,0,4) | Details |
| 15145080 | Johnson PJ, Bornstein JC: Neurokinin-1 and -3 receptor blockade inhibits slow excitatory synaptic transmission in myenteric neurons and reveals slow inhibitory input. Neuroscience. 2004;126(1):137-47. They were abolished by the 5-hydroxytryptamine (1A) receptor antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido) butyl]-piperazine (NAN-190), but unaffected by phentolamine, an alpha-adrenoceptor antagonist. This study investigated a similar role for neurokinin-1 receptors (NK (1) R) and compared the effect of selective receptor antagonists on non-cholinergic slow excitatory post-synaptic potentials (EPSPs) recorded in myenteric AH neurons of the guinea-pig ileum. |
4(0,0,0,4) | Details |
| 11714604 | Shaw D, Chicchi GG, Elliott JM, Kurtz M, Morrison D, Ridgill MP, Szeto N, Watt AP, Williams AR, Swain CJ: 2-Aryl NK (1) antagonists: optimisation of the amide substituent. Bioorg Med Chem Lett. 2001 Dec 3;11(23):3031-4. The 1-(2-methoxyphenyl) piperazine amide was identified as a major area of metabolism in the lead compound 1. |
2(0,0,0,2) | Details |