| Name | CD4 |
|---|---|
| Synonyms | CD4; CD4 antigen (p55); CD4 molecule; CD4mut; T cell antigen T4/LEU3; T cell surface glycoprotein CD4; T cell surface antigen T4/Leu 3; T cell surface glycoprotein CD4 precursor… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19620004 | Williams DH, Adam F, Fenwick DR, Fok-Seang J, Gardner I, Hay D, Jaiessh R, Middleton DS, Mowbray CE, Parkinson T, Perros M, Pickford C, Platts M, Randall A, Siddle D, Stephenson PT, Tran TD, Vuong H: Discovery of a small molecule inhibitor through interference with the gp120-CD4 interaction. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5246-9. Epub 2009 Jun 25. A series of piperazine derivatives were designed and synthesised as gp120-CD4 inhibitors. |
32(0,1,1,2) | Details |
| 19664921 | Wang T, Kadow JF, Zhang Z, Yin Z, Gao Q, Wu D, Parker DD, Yang Z, Zadjura L, Robinson BA, Gong YF, Blair WS, Shi PY, Yamanaka G, Lin PF, Meanwell NA: Inhibitors of HIV-1 attachment. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5140-5. Epub 2009 Jul 18. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of -based derivatives.. 4-- and 4-methoxy-1-(4-benzoylpiperazin-1-yl)-2-(1H-indol-3-yl) ethane-1,2-dione (2 and 3, respectively) have been characterized as potent inhibitors of HIV-1 attachment that interfere with the interaction of viral gp120 with the host cell receptor CD4. |
1(0,0,0,1) | Details |