Protein Information

Name TRPA1
Synonyms ANKTM 1; ANKTM1; Ankyrin like protein with transmembrane domains 1; Ankyrin like with transmembrane domains protein 1; TRPA 1; TRPA1; Transformation sensitive protein p120; Transient receptor potential cation channel subfamily A member 1…

Compound Information

Name piperazine
CAS piperazine

Reference List

PubMed Abstract RScore(About this table)
18667618 Fajardo O, Meseguer V, Belmonte C, Viana F: TRPA1 channels mediate cold temperature sensing in mammalian vagal sensory neurons: pharmacological and genetic evidence. J Neurosci. 2008 Jul 30;28(31):7863-75.

Thus, most cold-evoked responses were potentiated by cinnamaldehyde, menthol, icilin, and BCTC [4-(3-chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-tert-butyl-phenyl)-amide], agonists of TRPA1, and were inhibited by ruthenium red, camphor, and HC03001 [2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropy lphenyl) acetamide].
85(1,1,1,5) Details