| Name | transferase |
|---|---|
| Synonyms | 4' phosphopantetheinyl transferase; 4' phosphopantetheinyl transferase; AASD PPT; AASDHPPT; AASDPPT; Alpha aminoadipic semialdehyde dehydrogenase phosphopantetheinyl transferase; Aminoadipate semialdehyde dehydrogenase phosphopantetheinyl transferase; CGI 80… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12668011 | Perez M, Maraval C, Dumond S, Lamothe M, Schambel P, Etievant C, Hill B: Synthesis and evaluation of a novel series of farnesyl protein transferase inhibitors as non-peptidic CAAX tetrapeptide analogues. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1455-8. A novel series of compounds, derived from 4-amino-phenyl piperazine, has been designed to selectively inhibit farnesyl protein transferase (FPTase) as CAAX tetrapeptide analogues. |
82(1,1,1,2) | Details |
| 17606352 | Jiang X, Ling X, Han F, Li R, Cui J: Studies on the metabolism of 4-methyl-piperazine-1-carbodithioc acid 3-cyano-3,3-diphenylpropyl ester hydrochloride in rats by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. J Pharm Biomed Anal. 2007 Sep 3;44(5):1127-32. Epub 2007 May 25. M1 is the desmethyl metabolite and the acylation of M1 with N-acetyl transferase results in M6 (N-acetyl metabolite), M5 is N-formyl metabolite; M4 is phenyl monohydroxylation metabolite, M2 is the sulfine metabolite of TM208, and M3 is also an odd- added products which the possible oxidation site has described in this paper; M8 is the metabolite resulting from the replacement of '-C=S' with '-C=O', M7 is a ring-opened piperazine oxidation products to a kind of acid. |
31(0,1,1,1) | Details |
| 16343908 | Shin DS, Kim JH, Lee SK, Han DC, Son KH, Kim HM, Cheon HG, Kim KR, Sung ND, Lee SJ, Kang SK, Kwon BM: Synthesis and biological evaluation of dimeric cinnamaldehydes as potent antitumor agents. Bioorg Med Chem. 2006 Apr 15;14(8):2498-506. Epub 2005 Dec 15. It has been reported that 2-hydroxycinnamaldehyde and 2-benzoyl-oxycinnamaldehyde inhibited the activity of farnesyl protein transferase, angiogenesis, cell-cell adhesion, and tumor growth in vivo model. Especially, 2-piperazine derivative blocked in vivo growth of human colon tumor xenograft in nude mice at 10 mg/kg. |
1(0,0,0,1) | Details |
| 12543185 | Sashima S, Takahashi I, Nakazawa K: Identification and characterization of beta-D-galactosyl-transferase in chick corneas. Jpn J Ophthalmol. 2002 Nov-Dec;46(6):607-15. The partially purified enzyme showed an optimum pH at 7.0 [(N-[2-hydroxyethyl] piperazine-N'-[2-ethanesulfonic acid]) (HEPES) buffer]. |
1(0,0,0,1) | Details |