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Barthel A, Trieschmann L, Strohl D, Kluge R, Bohm G, Csuk R: Synthesis of dimeric quinazolin-2-one, 1,4-benzodiazepin-2-one, and isoalloxazine compounds as inhibitors of amyloid peptides association. Arch Pharm. 2009 Aug;342(8):445-52.
In addition, a piperazine spacered bis-isoalloxazine and a bis-riboflavin compound were prepared and their ability to interrupt the association of prion proteins and Alzheimer-specific Abeta peptides was investigated using a fast screening system based on flow cytometry. |
81(1,1,1,1) |
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