| 17688073 |
Schneider F, Mattern-Dogru E, Hillgenberg M, Alken RG: Changed phosphodiesterase selectivity and enhanced in vitro efficacy by selective deuteration of sildenafil. Arzneimittelforschung. 2007;57(6):293-8.
In order to explore whether selective deuteration of sildenafil affects selectivity and efficacy of the drug, the inhibitory activity of sildenafil (1-[4-ethoxy-3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo [4,3-d] pyri midin-5-yl) phenyl-sulfonyl] -4-methylpiperazine citrate, CAS 139755-83-2) and three deuterated sildenafil derivatives, D8-piperazine-sildenafil (BDD-10402), D3-methyl-D8-piperazine-sildenafil (BDD-10403) and D5-ethoxy-Sildenafil (BDD-10406) against phosphodiesterases 1-6 was compared. |
31(0,1,1,1) |
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