Protein Information

Name VLA 4
Synonyms CD49D; CD49d; CD49d antigen; IA4; ITGA 4; ITGA4; Integrin alpha 4; Integrin alpha IV…

Compound Information

Name piperazine
CAS piperazine

Reference List

PubMed Abstract RScore(About this table)
11865647 Lewis I, Rohde B, Mengus M, Weetall M, Maida S, Hugo R, Lake P: Combinatorial approaches to inhibitors of VLA-4: piperazine-peptoid-bisarylureas. Mol Divers. 2000;5(2):61-73.
31(0,1,1,1) Details
18160288 Saku O, Ohta K, Arai E, Nomoto Y, Miura H, Nakamura H, Fuse E, Nakasato Y: Synthetic study of VLA-4/VCAM-1 inhibitors: synthesis and structure-activity relationship of piperazinylphenylalanine derivatives. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1053-7. Epub 2007 Dec 14.

By changing components at the 4-position of piperazine and the terminal group of the amido bond, 12t was found to be the most potent of this series of compounds.
2(0,0,0,2) Details