| Name | catechol O methyltransferase |
|---|---|
| Synonyms | COMT; COMT protein; Catechol O methyltransferase; Catechol O methyltransferase isoform MB COMT; MB COMT; COMT proteins; Catechol O methyltransferases; Catechol O methyltransferase isoform MB COMTs |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12237326 | Bonifacio MJ, Archer M, Rodrigues ML, Matias PM, Learmonth DA, Carrondo MA, Soares-Da-Silva P: Kinetics and crystal structure of catechol-o-methyltransferase complex with co-substrate and a novel inhibitor with potential therapeutic application. Mol Pharmacol. 2002 Oct;62(4):795-805. The kinetics of inhibition by BIA 3-335 (1-[3,4-dihydroxy-5-nitrophenyl]-3-(N-3'-trifluormethylphenyl)-piperazine- dihydrochloride) were characterized using recombinant rat soluble COMT. |
37(0,1,1,7) | Details |
| 12438556 | Huotari M, Santha M, Lucas LR, Karayiorgou M, Gogos JA, Mannisto PT: Effect of uptake inhibition on brain catecholamine levels and locomotion in catechol-O-methyltransferase-disrupted mice. J Pharmacol Exp Ther. 2002 Dec;303(3):1309-16. In the present study we have characterized the role of COMT using COMT-deficient mice in conditions where DAT is inhibited by 1-[2-[bis (4-fluorophenyl) methoxy] ethyl]-4-(3-phenylpropyl)-piperazine (GBR 12909) or cocaine. |
37(0,1,1,7) | Details |
| 11375525 | Rodrigues ML, Archer M, Bonifacio MJ, Soares-da-Silva P, Carrondo MA: Crystallization and preliminary crystallographic characterization of catechol-O-methyltransferase in complex with its cosubstrate and an inhibitor. Acta Crystallogr D Biol Crystallogr. 2001 Jun;57(Pt 6):906-8. Epub 2001 May 25. Soluble rat COMT was expressed in Escherichia coli and the recombinant protein was crystallized with a new tight-binding inhibitor, BIA 3-335 [1-(3,4-dihydroxy-5-nitrophenyl)-3-(n-3'-trifluoromethylphenyl) piperazine- dihydrochloride]. |
33(0,1,1,3) | Details |