| Name | TNF alpha |
|---|---|
| Synonyms | Cachectin; DIF; TNF; TNF alpha; TNF a; TNFA; TNFSF 2; TNFSF2… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15665918 | Nikitin AA, Abidov MT, Kovalevskaya EO, Kalyuzhin OV: Search for potent modulators of cytokine production by macrophages. . Bull Exp Biol Med. 2004 Sep;138(3):259-61. We compared the effects of Tamerit, Polyoxidony, and Licopid on spontaneous and lipopolysaccharide-stimulated production of interleukin-1 and tumor necrosis factor by mouse peritoneal macrophages in vitro. |
1(0,0,0,1) | Details |
| 16498228 | Kuralay F, Altekin E, Yazlar AS, Onvural B, Goldeli O: Suppression of angioplasty-related inflammation by pre-procedural treatment with trimetazidine. Tohoku J Exp Med. 2006 Mar;208(3):203-12. In patients with coronary artery disease, undergoing PTCA, the effects of trimetazidine (TMZ), a piperazine-derivative anti-anginal drug, were studied on several indirect markers of systemic inflammatory response: tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP) and NO products and |
0(0,0,0,0) | Details |
| 16260582 | Kelso EB, Lockhart JC, Hembrough T, Dunning L, Plevin R, Hollenberg MD, Sommerhoff CP, McLean JS, Ferrell WR: Therapeutic promise of proteinase-activated receptor-2 antagonism in joint inflammation. J Pharmacol Exp Ther. 2006 Mar;316(3):1017-24. Epub 2005 Oct 31. Finally, we report the activity of a novel small molecule PAR2 antagonist, N1-3-methylbutyryl-N4-6-aminohexanoyl-piperazine (ENMD-1068), that dose dependently attenuated joint inflammation. |
0(0,0,0,0) | Details |
| 15454114 | Dyakonova VA, Dambaeva SV, Pinegin BV, Khaitov RM: Study of interaction between the polyoxidonium immunomodulator and the human immune system cells. Int Immunopharmacol. 2004 Dec 15;4(13):1615-23. Polyoxidonium (PO) is a high-molecular weight physiologically active compound with pronounced immunomodulating activity, an N-oxidized polyethylene-piperazine derivative. The analysis of immunomodulating effect produced by PO proved its stimulating activity on some cytokines production in vitro, e.g. interleukin 1beta (IL-1beta), tumor necrosis factor (TNF)-alpha and IL-6. |
1(0,0,0,1) | Details |
| 15892984 | Kubera M, Maes M, Kenis G, Kim YK, Lason W: Effects of and serotonergic agonists and antagonists on the production of tumor necrosis factor alpha and interleukin-6. Psychiatry Res. 2005 Apr 30;134(3):251-8. |
4(0,0,0,4) | Details |
| 12192139 | Tobe M, Isobe Y, Tomizawa H, Nagasaki T, Obara F, Matsumoto M, Hayashi H: Structure-activity relationships of 6-nitroquinazolines: dual-acting compounds with inhibitory activities toward both TNF-alpha production and T cell proliferation. Chem Pharm Bull. 2002 Aug;50(8):1073-80. The presence of the unsubstituted piperazine ring at the C (7)-position was required for both inhibitory activities. |
3(0,0,0,3) | Details |
| 11229767 | Tobe M, Isobe Y, Tomizawa H, Matsumoto M, Obara F, Nagasaki T, Hayashi H: Structure-activity relationships of quinazoline derivatives: dual-acting compounds with inhibitory activities toward both TNF-alpha production and T cell proliferation. Bioorg Med Chem Lett. 2001 Feb 26;11(4):545-8. A smaller N-substituent in the piperazine ring was required for inhibition of TNF-alpha production. |
83(1,1,1,3) | Details |
| 18771755 | Hwang J, Zheng LT, Ock J, Lee MG, Suk K: Anti-inflammatory effects of m-chlorophenylpiperazine in brain glia cells. Int Immunopharmacol. 2008 Dec 10;8(12):1686-94. Epub 2008 Sep 2. Our results showed that m-CPP significantly decreased the production of tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) in microglia and astrocyte cultures. m-CPP also attenuated the expression of inducible synthase and pro-inflammatory cytokines such as IL-1beta and TNF-alpha at mRNA levels. |
1(0,0,0,1) | Details |
| 17328048 | Kelso EB, Ferrell WR, Lockhart JC, Elias-Jones I, Hembrough T, Dunning L, Gracie JA, McInnes IB: Expression and proinflammatory role of proteinase-activated receptor 2 in rheumatoid synovium: ex vivo studies using a novel proteinase-activated receptor 2 antagonist. Arthritis Rheum. 2007 Mar;56(3):765-71. Importantly, spontaneous release of tumor necrosis factor alpha and interleukin-1beta from RA synovium was substantially inhibited by ENMD-1068, in a dose-dependent manner. |
1(0,0,0,1) | Details |