| Name | bradykinin |
|---|---|
| Synonyms | Alpha 2 thiol proteinase inhibitor; BDK; Bradykinin; KNG; KNG 1; KNG1; Kininogen; Kininogen 1 precursor… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16226247 | Kam YL, Ro JY, Kim HJ, Choo HY: Antagonistic effects of novel non-peptide chlorobenzhydryl piperazine compounds on contractile response to bradykinin in the guinea-pig ileum. Eur J Pharmacol. 2005 Oct 31;523(1-3):143-50. Epub 2005 Oct 13. Two novel compounds, N-phenylacetyl-N'-(4-methoxybenzyl)-N''-1-(4-chlorobenzhydryl) piperazine iminodiacetic acid triamide (compound I) and N-phenylacetyl-N'-(4-methylbenzyl)-N''-1-(4-chlorobenzhydryl) piperazine iminodiacetic acid triamide (compound II), designed and synthesized as novel non-peptide bradykinin B2 receptor antagonists, were studied for their functional activities in isolated guinea-pig ileum smooth muscle. |
122(1,2,3,7) | Details |
| 15895105 | Weston AH, Feletou M, Vanhoutte PM, Falck JR, Campbell WB, Edwards G: Bradykinin-induced, endothelium-dependent responses in porcine coronary arteries: involvement of potassium channel activation and epoxyeicosatrienoic acids. Br J Pharmacol. 2005 Jul;145(6):775-84. After gap junction blockade with HEPES, (N-(2-hydroxyethyl) piperazine-N'-(2-ethanesulphonic acid)) hyperpolarization of the endothelium by 100 nM bradykinin was abolished by TRAM-39 plus apamin, whereas myocyte hyperpolarization still occurred (12.9 +/- 1.0 mV, n=4). |
38(0,1,1,8) | Details |
| 15186838 | Kam YL, Rhee SJ, Choo HY: Solution-phase combinatorial synthesis of nonpeptide bradykinin antagonists. Bioorg Med Chem. 2004 Jul 1;12(13):3543-52. We describe the solution-phase combinatorial synthesis and pharmacological effect of fifty N,N (')-substituted-N"-1-(4-chlorobenzhydryl) piperazine iminodiacetic acid triamide derivatives as nonpeptide B2 antagonists. |
2(0,0,0,2) | Details |
| 16759102 | Fattori D, Rossi C, Fincham CI, Berettoni M, Calvani F, Catrambone F, Felicetti P, Gensini M, Terracciano R, Altamura M, Bressan A, Giuliani S, Maggi CA, Meini S, Valenti C, Quartara L: Design and synthesis of novel sulfonamide-containing bradykinin hB2 receptor antagonists. 1. J Med Chem. 2006 Jun 15;49(12):3602-13. The following structural features were selected: a 2,4-dimethylquinoline moiety and a piperazine linker acylated with a basic amino acid. |
1(0,0,0,1) | Details |