| Name | HDAC |
|---|---|
| Synonyms | HD7; HDAC 7; HDAC7; HD7B; HD9; HDAC; HDAC 9; HDAC7B… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19111466 | Smil DV, Manku S, Chantigny YA, Leit S, Wahhab A, Yan TP, Fournel M, Maroun C, Li Z, Lemieux AM, Nicolescu A, Rahil J, Lefebvre S, Panetta A, Besterman JM, Deziel R: Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Feb 1;19(3):688-92. Epub 2008 Dec 14. In an effort to identify HDAC isoform selective inhibitors, we designed and synthesized novel, chiral 3,4-dihydroquinoxalin-2 (1H)-one and piperazine-2,5-dione aryl hydroxamates showing selectivity (up to 40-fold) for human HDAC6 over other class I/IIa HDACs. |
32(0,1,1,2) | Details |
| 20217840 | Chakrabarty S, Jasmine, Bhadaliya C, Sinha BN, Mahesh A, Bai H, Blond SY, Jayaprakash V: Inhibitors of human histone deacetylase: synthesis and enzyme assay of hydroxamates with piperazine linker. Arch Pharm. 2010 Mar;343(3):167-72. The histone deacetylase (HDAC) enzyme plays an important role in gene transcription. |
1(0,0,0,1) | Details |
| 17827005 | Anandan SK, Ward JS, Brokx RD, Denny T, Bray MR, Patel DV, Xiao XY: Design and synthesis of thiazole-5-hydroxamic acids as novel histone deacetylase inhibitors. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5995-9. Epub 2007 Aug 19. We have designed and synthesized a series of structurally novel hydroxamic acid-based histone deacetylase (HDAC) inhibitors characterized by a zinc chelating head group attached directly to a thiazole ring. The thiazole ring connects to a piperazine spacer, which is capped with a sulfonamide group. |
2(0,0,0,2) | Details |
| 16670375 | Cassel S, Carouge D, Gensburger C, Anglard P, Burgun C, Dietrich JB, Aunis D, Zwiller J: Fluoxetine and cocaine induce the epigenetic factors MeCP2 and MBD1 in adult rat brain. Mol Pharmacol. 2006 Aug;70(2):487-92. Epub 2006 May 2. Once bound to methylated CpG sites, methyl-CpG-binding protein 2 (MeCP2) is thought to silence transcription of downstream genes by recruiting a histone deacetylase (HDAC). Mecp2 was not induced by repeated injections of 1-(2-bis (4-fluorphenyl)-methoxy)-ethyl)-4-(3-phenyl-propyl) piperazine (GBR-12909) or nortriptyline. |
1(0,0,0,1) | Details |