| Name | 5 HT4 |
|---|---|
| Synonyms | 5 HT4; serotonin receptor; 5 hydroxytryptamine 4 receptor; 5 hydroxytryptamine receptor 4; 5 HT 4; 5 HT4R; 5 hydroxytryptamine (serotonin) receptor 4; Cardiac 5 HT4 receptor… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12801225 | Berque-Bestel I, Soulier JL, Giner M, Rivail L, Langlois M, Sicsic S: Synthesis and characterization of the first fluorescent antagonists for human 5-HT4 receptors. J Med Chem. 2003 Jun 19;46(13):2606-20. Fluorescent antagonists for human 5-HT (4) receptors were synthesized based on ML10302 1, a potent 5-HT (4) receptor agonist and on piperazine analogue 2. |
83(1,1,1,3) | Details |
| 15450869 | Lehr T, Schipp R: An antagonistic receptor system in the auricles of the systemic heart complex of Sepia officinalis L. (Cephalopoda) shows 5-HT1 and 5-HT4 subtype properties. Comp Biochem Physiol C Toxicol Pharmacol. 2004 Jun;138(2):213-9. |
3(0,0,0,3) | Details |
| 16728720 | Lau DH, Thompson CS, Bellringer JF, Thomas PJ, Mumtaz FH, Morgan RJ, Mikhailidis DP: Doxazosin and receptor (1A, 2A, and 4) antagonists inhibit -mediated human cavernosal contraction. J Androl. 2006 Sep-Oct;27(5):679-85. Epub 2006 May 25. The effect of on human cavernosal tissues, as well as those of doxazosin (shown previously to have inhibitory action), ketanserin (5-HT (2A) receptor antagonist), NAN-190 (5-HT (1A) receptor antagonist), and SB 203186 (5-HT (4) receptor antagonist) on -mediated effects, were assessed using the organ bath technique, including electrical field stimulation study (EFS). |
3(0,0,0,3) | Details |
| 15582454 | Chu W, Tu Z, McElveen E, Xu J, Taylor M, Luedtke RR, Mach RH: Synthesis and in vitro binding of N-phenyl piperazine analogs as potential D3 receptor ligands. Bioorg Med Chem. 2005 Jan 3;13(1):77-87. Binding studies were also conducted to determine if the compounds bound to sigma (sigma (1) and sigma (2)) and (5-HT (1A), 5-HT (2A), 5-HT (2B), 5-HT (2C), 5-HT (3), 5-HT (4), 5-HT (5), 5-HT (6), and 5-HT (7)) receptors. |
1(0,0,0,1) | Details |
| 17584957 | Papageorgiou A, Denef C: Stimulation of growth hormone release by in cultured rat anterior pituitary cell aggregates: evidence for mediation by 5-HT2B, 5-HT7, 5-HT1B, and ketanserin-sensitive receptors. Endocrinology. 2007 Sep;148(9):4509-22. Epub 2007 Jun 21. In aggregates cultured with 1 nM for expression of the 5-HT4, -5, and -6 receptor (R), promptly stimulated GH secretion with a dose dependency between 1 and 10 nM. Basal GH release was stimulated by the 5-HTR2 agonists 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, m-chlorophenyl piperazine, and alpha-methyl 5-carboxytryptamine (agonist at 5-HTR1, -5, and -7); (preferential 5-HTR7 agonist); and the selective 5-HTR1B agonist CP93129 but not the 5-HTR1A agonists 7-(dipropylamino) tetralin-1-ol-8--2-(di-n-propylamino) tetralin and the 5-HTR1B/D agonist |
1(0,0,0,1) | Details |
| 14656323 | Paolucci E, Berretta N, Tozzi A, Bernardi G, Mercuri NB: Depression of mGluR-mediated IPSCs by in neurons of the rat substantia nigra pars compacta. Eur J Neurosci. 2003 Nov;18(10):2743-50. Similar results were obtained with alpha-methyl- and but not with 5-carboxamidotryptamine or 1-(3-chlorophenyl) piperazine. Our results demonstrate a powerful inhibition of the mGluR-IPSC by in midbrain neurons, most probably through stimulation of 5-HT2A and 5-HT4 receptors. |
1(0,0,0,1) | Details |
| 18295406 | Qu CL, Huo FQ, Huang FS, Li YQ, Tang JS, Jia H: The role of receptor subtypes in the ventrolateral orbital cortex of -induced antinociception in the rat. Neuroscience. 2008 Mar 18;152(2):487-94. Epub 2007 Sep 21. This study focused on the effects of microinjection in the VLO of lightly anesthetized male rats on the radiant heat-evoked tail flick (TF) reflex, as well as the influence of 5-HT (1A), 5-HT (2), 5-HT (3), and 5-HT (4) receptor subtype antagonists on the effect of Pretreatment with receptor antagonists (1-(2-methoxyphenyl)-4-[4-(2-phthalimido) butyl] piperazine hydrobromide (NAN-190), cyproheptadine hydrochloride (CPT) and 1-methyl-N-(8-methyl-8-azabicyclo [3.2.3]-oct-3-yl)-1H-indazole-3-carboxami de salt (LY-278,584)), specific for 5-HT (1A), 5-HT (2) and 5-HT (3) receptors, respectively, partially reversed the -evoked inhibition. |
1(0,0,0,1) | Details |
| 11167653 | Testa R, Guarneri L, Angelico P, Velasco C, Poggesi E, Cilia A, Leonardi A: Effect of different 5-hydroxytryptamine receptor subtype antagonists on the micturition reflex in rats. BJU Int. 2001 Feb;87(3):256-64. The tested antagonists of 5-HT2, 5-HT3, 5-HT4, and 5-HT6 serotoninergic subtypes were poorly active or inactive in the model. |
1(0,0,0,1) | Details |
| 16710314 | McCreary AC, Glennon JC, Ashby CR Jr, Meltzer HY, Li Z, Reinders JH, Hesselink MB, Long SK, Herremans AH, van Stuivenberg H, Feenstra RW, Kruse CG: SLV313 (1-(2,3-dihydro-benzo [1,4] dioxin-5-yl)-4- [5-(4--phenyl)-pyridin-3-ylmethyl]-piperazine monohydrochloride): a novel dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug. Neuropsychopharmacology. 2007 Jan;32(1):78-94. Epub 2006 May 17. |
0(0,0,0,0) | Details |
| 16553644 | Kitazawa T, Ukai H, Komori S, Taneike T: Pharmacological characterization of -induced contraction in the chicken gastrointestinal tract. Auton Autacoid Pharmacol. 2006 Apr;26(2):157-68. The proventriculus (area of stomach adjacent to the oesophagus) and ileum are examined. applied cumulatively caused sustained contraction of the proventriculus that was not decreased by tetrodotoxin, atropine or l-nitro- methylester (l-NAME). alpha-Methyl- showed the same potency as that of indicating the involvement of the 5-HT (2) receptor. (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane (DOI), and 1-(3-chlorophenyl) piperazine hydrochloride (mCPP) were potent, and 2-methyl-5-HT, 5-carboxamidotryptamine, BW723C86 and 6-chloro-2-(1-piperazinyl) pyrazine hydrochloride (MK212) were moderate, but (+/-)-8--2-dipropylaminotetralin hydrobromide (8-OH-DPAT), [endo-N-8-methyl-8-azabicyclo-(3,2,1) oct-3-yl]-2,3-dihydro-(1-methyl) ethyl -2-oxo-1H-benzimidazol-1-carboxamide (BIMU-8) and cisapride were weak agonists. |
0(0,0,0,0) | Details |