| Name | 5 HT 2B |
|---|---|
| Synonyms | 5 hydroxytryptamine receptor 2B; 5 HT(2B); 5 HT 2B; 5 HT2B; 5 hydroxytryptamine (serotonin) receptor 2B; 5 hydroxytryptamine 2B receptor; HTR2B; Serotonin 5 HT 2B receptor… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19875674 | Rasbach KA, Funk JA, Jayavelu T, Green PT, Schnellmann RG: 5-hydroxytryptamine receptor stimulation of mitochondrial biogenesis. J Pharmacol Exp Ther. 2010 Feb;332(2):632-9. Epub 2009 Oct 29. Reverse transcription-polymerase chain reaction analysis confirmed the presence of 5-HT2A, 5-HT2B, and 5-HT2C receptor mRNA in RPTC. |
1(0,0,0,1) | Details |
| 12644293 | Nic Dhonnchadha BA, Bourin M, Hascoet M: Anxiolytic-like effects of 5-HT2 ligands on three mouse models of anxiety. Behav Brain Res. 2003 Mar 18;140(1-2):203-14. DOI, a preferential 5-HT (2A) agonist (0.5-8 mg/kg) and BW 723C86, a 5-HT (2B) agonist (8 and 16 mg/kg) provoked an anxiolytic-like response in the FPT. |
1(0,0,0,1) | Details |
| 11298663 | Martin RS, Martin GR: Investigations into migraine pathogenesis: time course for effects of m-CPP, BW723C86 or glyceryl trinitrate on appearance of Fos-like immunoreactivity in rat trigeminal nucleus caudalis (TNC). Cephalalgia. 2001 Feb;21(1):46-52. Therefore, we measured the effects of 5-HT2B agonists (m-CPP or BW723C86) or GTN on trigeminal nerves by quantifying Fos expression in the rat TNC. m-CPP (0.1 mg/kg, i.v.) induced time-dependent elevations in Fos-LI in the rat TNC 2 h and 8 h after injection. |
1(0,0,0,1) | Details |
| 16553644 | Kitazawa T, Ukai H, Komori S, Taneike T: Pharmacological characterization of -induced contraction in the chicken gastrointestinal tract. Auton Autacoid Pharmacol. 2006 Apr;26(2):157-68. The proventriculus (area of stomach adjacent to the oesophagus) and ileum are examined. applied cumulatively caused sustained contraction of the proventriculus that was not decreased by tetrodotoxin, atropine or l-nitro- methylester (l-NAME). alpha-Methyl- showed the same potency as that of indicating the involvement of the 5-HT (2) receptor. (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane (DOI), and 1-(3-chlorophenyl) piperazine hydrochloride (mCPP) were potent, and 2-methyl-5-HT, 5-carboxamidotryptamine, BW723C86 and 6-chloro-2-(1-piperazinyl) pyrazine hydrochloride (MK212) were moderate, but (+/-)-8--2-dipropylaminotetralin hydrobromide (8-OH-DPAT), [endo-N-8-methyl-8-azabicyclo-(3,2,1) oct-3-yl]-2,3-dihydro-(1-methyl) ethyl -2-oxo-1H-benzimidazol-1-carboxamide (BIMU-8) and cisapride were weak agonists. Correlation of pEC (50) values of these agonists with documented pEC (50) values for 5-HT (2C) receptor was higher than 5-HT (2A) and 5-HT (2B). |
1(0,0,0,1) | Details |
| 11888572 | Fone KC, Topham IA: Alteration in agonist-induced behaviour following a implant in adult rats. Pharmacol Biochem Behav. 2002 Apr;71(4):815-23. The elevation in plasma and back muscle contractions evoked by the 5-HT (2A) agonist DOI (1 mg/kg ip) were attenuated, whilst wet-dog shakes were enhanced by treatment. 5-HT (2B) agonist-induced behaviour and the hypolocomotion and hypophagia induced by the 5-HT (2C) agonist m-CPP (2.5 mg/kg ip) were unaltered but the mCPP-induced elevation in was abolished by treatment. |
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| 19640898 | Miyazato M, Kaiho Y, Kamo I, Kitta T, Chancellor MB, Sugaya K, Arai Y, de Groat WC, Yoshimura N: Role of spinal serotonergic pathways in sneeze-induced urethral continence reflex in rats. Am J Physiol Renal Physiol. 2009 Oct;297(4):F1024-31. Epub 2009 Jul 29. To clarify the role of spinal serotonergic mechanisms in preventing stress urinary incontinence (SUI) during sneezing, we investigated the effect of intrathecal (it) application of 8-OH-DPAT (a 5-HT (1A) agonist), mCPP (a 5-HT (2B/2C) agonist), and fluoxetine (a reuptake inhibitor) using a rat model that can examine the neurally evoked continence reflex during sneezing. |
1(0,0,0,1) | Details |
| 12892833 | Zanoveli JM, Nogueira RL, Zangrossi H Jr: in the dorsal periaqueductal gray modulates inhibitory avoidance and one-way escape behaviors in the elevated T-maze. Eur J Pharmacol. 2003 Jul 25;473(2-3):153-61. In these two test conditions, intra-dorsal periaqueductal gray injection of the endogenous agonist or the 5-HT (2B/2C) receptor agonist m-chlorophenylpiperazine (mCPP) enhanced inhibitory avoidance, suggesting an anxiogenic effect. |
1(0,0,0,1) | Details |
| 18644367 | Moran A, Ortiz de Urbina AV, Martin ML, Garcia M, Rodriguez-Barbero A, Dorado F, San Roman L: Characterization of contractile 5-hydroxytryptamine receptor subtypes in the in situ autoperfused kidney in the anaesthetized rat. Eur J Pharmacol. 2008 Sep 11;592(1-3):133-7. Epub 2008 Jul 4. The selective 5-HT2 receptor agonist alpha-methyl- (alpha-methyl- and the non-selective 5-HT2C receptor agonist (1-(3-chlorophenyl) piperazine), m-CPP, caused a local vasoconstrictor effect in the autoperfused rat kidney, whereas BW723C86, a selective 5-HT2B receptor agonist, the 5-HT1 receptor agonist 5-carboxamidotryptamine, 5-CT, and the selective 5-HT3 receptor agonist m-CPBG (1-(m-chlorophenyl)-biguanide) did not modify the renal perfusion pressure. |
0(0,0,0,0) | Details |
| 19699736 | Moran A, de Urbina AV, Martin ML, Rodriguez-Barbero A, Roman LS: Characterization of the contractile 5-hydroxytryptamine receptor in the autoperfused kidney of L-NAME hypertensive rats. Eur J Pharmacol. 2009 Oct 12;620(1-3):90-6. Epub 2009 Aug 21. The selective 5-HT (2B) receptor agonist BW723C86, the non-selective 5-HT (2C) receptor agonist (1-(3-chlorophenyl) piperazine), m-CPP, the (1) receptor agonist 5-carboxamidotryptamine (5-CT) and the selective 5-HT (3) receptor agonist (1-(m-chlorophenyl)-biguanide), m-CPBG, did not modify renal perfusion pressure. |
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| 12716945 | Zhang ZW: induces tonic firing in layer V pyramidal neurons of rat prefrontal cortex during postnatal development. J Neurosci. 2003 Apr 15;23(8):3373-84. The excitatory effects of at younger ages were attributed to 5-HT2A receptors because the effects were mimicked by the 5-HT2 agonist alpha-methyl- but not by the 5-HT3 agonist 1-(m-chlorophenyl)-biguanide, nor by the 5-HT2B/2C agonist 1-(3-chlorophenyl) piperazine, and were blocked by the 5-HT2A antagonists ketanserin and alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol. |
0(0,0,0,0) | Details |
| 16165167 | Walker EA, Kohut SJ, Hass RW, Brown EK Jr, Prabandham A, Lefever T: Selective and nonselective antagonists block the aversive stimulus properties of MK212 and m-chlorophenylpiperazine (mCPP) in mice. Neuropharmacology. 2005 Dec;49(8):1210-9. Epub 2005 Sep 13. Selective 5-HT (2B/2C) antagonist SB206,553 blocked both MK212- and mCPP-induced conditioned taste aversion although selective 5-HT (2B/2C) antagonist SB200,646 only blocked mCPP-induced conditioned taste aversion. |
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| 15380867 | Landry ES, Guertin PA: Differential effects of 5-HT1 and 5-HT2 receptor agonists on hindlimb movements in paraplegic mice. Prog Neuropsychopharmacol Biol Psychiatry. 2004 Sep;28(6):1053-60. Altogether, these results demonstrate that 5-HT (2A/2C) receptor agonists promote locomotion while 5-HT (1B) and 5-HT (2B/2C) receptor agonists interfere with locomotor genesis in the hindlimbs of complete paraplegic mice. |
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| 14517765 | Sugimoto Y, Inoue K, Yamada J: Involvement of 5-HT (2) receptor in -induced hyperglycemia in mice. Horm Metab Res. 2003 Sep;35(9):511-6. i. p.-induced hyperglycemia was antagonized by the 5-HT (2C/2B) receptor agonist 1-(3-chlorophenyl) piperazine (mCPP), while the 5-HT (2B) receptor agonist BW 723C86 had no effect. |
0(0,0,0,0) | Details |
| 12734389 | Hajos M, Hoffmann WE, Weaver RJ: Regulation of septo-hippocampal activity by 5-hydroxytryptamine (2C) receptors. J Pharmacol Exp Ther. 2003 Aug;306(2):605-15. Epub 2003 May 6. Intravenous administration of 5-HT2C receptor agonists 1-(3-chlorophenyl) piperazine dihydrochloride (m-CPP) and [S]-2-(chloro-5--indol-1-yl)-1-methyl-ethylamine (Ro 60-0175) dose dependently inhibited firing activity most of the recorded MS/DBv neurons and abolished theta oscillation in all tested MS/DBv and hippocampal neurons. |
0(0,0,0,0) | Details |
| 16710314 | McCreary AC, Glennon JC, Ashby CR Jr, Meltzer HY, Li Z, Reinders JH, Hesselink MB, Long SK, Herremans AH, van Stuivenberg H, Feenstra RW, Kruse CG: SLV313 (1-(2,3-dihydro-benzo [1,4] dioxin-5-yl)-4- [5-(4--phenyl)-pyridin-3-ylmethyl]-piperazine monohydrochloride): a novel dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug. Neuropsychopharmacology. 2007 Jan;32(1):78-94. Epub 2006 May 17. |
0(0,0,0,0) | Details |
| 11754579 | Brea J, Rodrigo J, Carrieri A, Sanz F, Cadavid MI, Enguix MJ, Villazon M, Mengod G, Caro Y, Masaguer CF, Ravina E, Centeno NB, Carotti A, Loza MI: New 5-HT (2A), 5-HT (2B), and 5-HT (2C) receptor antagonists: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl) benzo and heterocycloalkanones. J Med Chem. 2002 Jan 3;45(1):54-71. Significant selectivity at the 5-HT (2B) receptor vs 5-HT (2C) was observed with 1-1 [(1-oxo-1,2,3,4-tetrahydro-3-naphthyl) methyl]-4-[3-(p-fluorobenzoyl) pro pyl] piperazine (more than 100-fold higher). |
88(1,1,1,8) | Details |
| 15638778 | Isaac M: Serotonergic 5-HT2C receptors as a potential therapeutic target for the design antiepileptic drugs. Curr Top Med Chem. 2005;5(1):59-67. More specifically, the recent finding that the 5-HT2B/2C receptor agonist, 1-(m-chlorophenyl)-piperazine (mCPP) is anticonvulsant has kindled an interest into the investigation of the serotonergic 5-HT2C receptor subtype as a potential target for the treatment of epilepsy. |
81(1,1,1,1) | Details |
| 15107597 | Kovacs A, Gacsalyi I, Wellmann J, Schmidt E, Szucs Z, Dubreuil V, Nicolas JP, Boutin J, Bozsing D, Egyed A, Tihanyi K, Spedding M, Szenasi G: Effects of EGIS-7625, a selective and competitive 5-HT2B receptor antagonist. Cardiovasc Drugs Ther. 2003 Sep-Nov;17(5-6):427-34. Our aim was to specify the 5-HT (2) subtype selectivity of EGIS-7625 (1-benzyl-4-[(2-nitro-4-methyl-5-amino)-phenyl]-piperazine), a new 5-HT (2B) ligand, in receptor binding studies and characterize its pharmacology at 5-HT (2A), 5-HT (2B) and 5-HT (2C) receptors in in vivo experiments and in isolated organs, in vitro. |
35(0,1,1,5) | Details |
| 11101359 | Ravina E, Casariego I, Masaguer CF, Fontenla JA, Montenegro GY, Rivas ME, Loza MI, Enguix MJ, Villazon M, Cadavid MI, Demontis GC: Conformationally constrained butyrophenones with affinity for (D (1), D (2), D (4)) and (5-HT (2A), 5-HT (2B), 5-HT (2C)) receptors: synthesis of aminomethylbenzo [b] furanones and their evaluation as antipsychotics. J Med Chem. 2000 Nov 30;43(24):4678-93. A series of novel conformationally restricted butyrophenones (6-aminomethyl-4,5,6,7-tetrahydrobenzo [b] furan-4-ones bearing 4-(6-fluorobenzisoxazolyl) piperidine, 4-(p-fluorobenzoyl) piperidine, 4-(o-methoxyphenyl) piperazine, 4-(2-pyridyl) piperazine, 4-(2-pyrimidinyl) piperazine, or linear butyro (or valero) phenone fragments) were prepared and evaluated as antipsychotic agents by in vitro assays for affinity for receptors (D (1), D (2), D (4)) and serotonin receptors (5-HT (2A), 5-HT (2B), 5-HT (2C)), by neurochemical studies, and by in vivo assays for antipsychotic potential and the risk of inducing extrapyramidal side effects. |
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| 12231467 | Arjona AA, Pooler AM, Lee RK, Wurtman RJ: Effect of a 5-HT (2C) agonist, dexnorfenfluramine, on amyloid precursor protein metabolism in guinea pigs. Brain Res. 2002 Sep 27;951(1):135-40. Chronic administration of mCPP (1-(m-chlorophenyl) piperazine) (2 mg/kg bid, i.p.), a 5-HT (2B/2C) agonist, for 9 days also increased CSF APP (s) levels (P <0.5) when measured 2 h after the drug's last administration; hippocampal and cortical APP (h) levels were unaffected. |
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| 15032678 | Poissonnet G, Parmentier JG, Boutin JA, Goldstein S: The emergence of selective 5-HT 2B antagonists structures, activities and potential therapeutic applications. Mini Rev Med Chem. 2004 Mar;4(3):325-30. Indeed, four structural classes belonging to the piperazine, naphthylpyrimidine and tetrahydro-beta-carboline scaffolds were reported. |
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| 12885436 | Castro L, Athanazio R, Barbetta M, Ramos AC, Angelo AL, Campos I, Varjao B, Ferreira H, Fregoneze J, de Castro e Silva E: Central 5-HT2B/2C and 5-HT3 receptor stimulation decreases salt intake in -depleted rats. Brain Res. 2003 Aug 15;981(1-2):151-9. |
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| 12603368 | Johnson KW, Nelson DL, Dieckman DK, Wainscott DB, Lucaites VL, Audia JE, Owton WM, Phebus LA: Neurogenic dural protein extravasation induced by meta-chlorophenylpiperazine (mCPP) involves and 5-HT2B receptor activation. Cephalalgia. 2003 Mar;23(2):117-23. |
4(0,0,0,4) | Details |
| 11205420 | Duxon MS, Stretton J, Starr K, Jones DN, Holland V, Riley G, Jerman J, Brough S, Smart D, Johns A, Chan W, Porter RA, Upton N: Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement. Psychopharmacology. 2001 Jan 1;153(2):203-9. METHODS: Male rats, habituated to clear Perspex behavioural observation boxes, were pretreated with antagonists with mixed selectivity for OX1, OX2, 5-HT2B and 5-HT2C receptor subtypes prior to the administration of orexin-A and the intense grooming response elicited by this peptide assessed. |
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| 17584957 | Papageorgiou A, Denef C: Stimulation of growth hormone release by in cultured rat anterior pituitary cell aggregates: evidence for mediation by 5-HT2B, 5-HT7, 5-HT1B, and ketanserin-sensitive receptors. Endocrinology. 2007 Sep;148(9):4509-22. Epub 2007 Jun 21. Basal GH release was stimulated by the 5-HTR2 agonists 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, m-chlorophenyl piperazine, and alpha-methyl 5-carboxytryptamine (agonist at 5-HTR1, -5, and -7); (preferential 5-HTR7 agonist); and the selective 5-HTR1B agonist CP93129 but not the 5-HTR1A agonists 7-(dipropylamino) tetralin-1-ol-8--2-(di-n-propylamino) tetralin and the 5-HTR1B/D agonist |
4(0,0,0,4) | Details |
| 18439428 | Takeda H, Sadakane C, Hattori T, Katsurada T, Ohkawara T, Nagai K, Asaka M: Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism. Gastroenterology. 2008 Jun;134(7):2004-13. Epub 2008 Feb 29. In addition, binding affinities of rikkunshito components were determined in receptor-binding assays using 5-HT2B and 5-HT2C receptors. |
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| 12062579 | Castro L, Maldonado I, Campos I, Varjao B, Angelo AL, Athanazio RA, Barbetta MC, Ramos AC, Fregoneze JB, De Castro e Silva E: Central administration of mCPP, a 5-HT (2B/2C) agonist, decreases water intake in rats. Pharmacol Biochem Behav. 2002 Jul;72(4):891-8. In the present study, we investigated in rats the effect of third ventricle injections of 1-(3-chlorophenyl) piperazine (mCPP), a 5-HT (2) receptor agonist, on water intake induced by three different physiological stimuli: fluid deprivation, acute salt load and hypovolemia. |
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| 11906967 | Centurion D, Ortiz MI, Saxena PR, Villalon CM: The atypical 5-HT2 receptor mediating tachycardia in pithed rats: pharmacological correlation with the 5-HT2A receptor subtype. Br J Pharmacol. 2002 Mar;135(6):1531-9. Since 5-HT (2) receptors consist of 5-HT (2A), 5-HT (2B) and 5-HT (2C) subtypes, this study investigated if these subtypes mediate the above response. 2. In pithed rats, intraperitoneally (i.p.) pre-treated with reserpine (5 mg kg (-1)), intravenous (i.v.) administration of 5-HT, 5- (5-MeO-T), 1-(3-chlorophenyl) piperazine (mCPP) and 5-carboxamidotryptamine (5-CT) (10, 30, 100 and 300 microg kg (-1) each), produced dose-dependent tachycardic responses. |
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| 17936345 | Yonezawa A, Yoshizumi M, Ebiko M, Ise SN, Watanabe C, Mizoguchi H, Kimura Y, Sakurada S: Ejaculatory response induced by a 5-HT2 receptor agonist m-CPP in rats: differential roles of 5-HT2 receptor subtypes. Pharmacol Biochem Behav. 2008 Feb;88(4):367-73. Epub 2007 Sep 18. It has been reported that systemic administration of m-CPP (1-[3-chlorophenyl] piperazine hydrochloride), a 5-HT (2) receptor agonist, produces a 5-HT (2C) receptor-mediated penile erections and self-grooming in rats. The proejaculatory effect of m-CPP was also attenuated by ketanserin (0.3 and 1.0 mg/kg, i.p.), a 5-HT (2A) receptor antagonist, whereas SB204741 (0.1 and 0.3 mg/kg, i.p.), a selective 5-HT (2B) receptor antagonist, significantly potentiated the m-CPP-induced ejaculatory response. |
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| 11124393 | Schreiber R, Selbach K, Asmussen M, Hesse D, de Vry J: Effects of (1/2) receptor agonists on dark-phase food and water intake in rats. Pharmacol Biochem Behav. 2000 Oct;67(2):291-305. The following agonists were tested: ipsapirone [preferred receptor (s) and dose range in mg/kg, IP: 5-HT (1A) and 3-30, respectively], CP-94,253 (5-HT (1B); 0.3-3), TFMPP (5-HT (1B/2C); 0. 3-10), m-CPP (5-HT (2C/1B); 0.3-10), ORG 37684 (5-HT (2C); 0.3-10), BW 723C86 (5-HT (2B); 3-30) and DOI (5-HT (2A/2C); 0.3-3). |
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| 15892984 | Kubera M, Maes M, Kenis G, Kim YK, Lason W: Effects of and serotonergic agonists and antagonists on the production of tumor necrosis factor alpha and interleukin-6. Psychiatry Res. 2005 Apr 30;134(3):251-8. The specific aims were to examine the effects of p-chlorophenylalanine (PCPA), a depleting agent, flesinoxan, a 5-HT (1A) agonist, m-chlorophenylpiperazine (mCPP), a 5-HT (2B/2C) agonist, and ritanserin, a 5-HT (2A/2C) antagonist, on the production of the above cytokines. |
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| 11509227 | Vickers SP, Easton N, Malcolm CS, Allen NH, Porter RH, Bickerdike MJ, Kennett GA: Modulation of 5-HT (2A) receptor-mediated head-twitch behaviour in the rat by 5-HT (2C) receptor agonists. Pharmacol Biochem Behav. 2001 Jul-Aug;69(3-4):643-52. The pharmacology of several commonly described (5-HT)(2C) receptor agonists was investigated in vivo and in vitro at rat 5-HT (2A), 5-HT (2B), and 5-HT (2C) receptors. The preferential 5-HT (2C) receptor agonists Ro 60-0175, 6-chloro-2-[1-piperazinyl]-pyrazine HCl (MK-212), 1-(3-chlorophenyl) piperazine hydrochloride (mCPP), 1-(3-trifluoromethylphenyl) piperazine hydrochloride (TFMPP), and (S)-3-[(2,3-dihydro-5-methoxy-1H-inden-4-yl) oxy]-pyrollidine HCl (ORG-37684), the 5-HT (2A/2C) receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI), the 5-HT (2B) receptor agonist 1-[5-thienylmethoxy-1-1H-3-indoyl] propan-2-amine hydrochloride (BW-723C86), and nor-D-fenfluramine were administered to rats subsequent to an acute challenge of SB-242084. |
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| 18582863 | Kimura Y, Naitou Y, Wanibuchi F, Yamaguchi T: 5-HT (2C) receptor activation is a common mechanism on proerectile effects of apomorphine, and melanotan-II in rats. Eur J Pharmacol. 2008 Jul 28;589(1-3):157-62. Epub 2008 May 24. In this study, in order to clarify these matters, we examined the effects of a selective 5-HT (2B)/5-HT (2C) receptors antagonist, 1-(1-methylindol-5-yl)-3-(3-pyridyl) urea (SB200646) and a selective 5-HT (2C) receptor antagonist, 6-chloro-5-methyl-1-[6-(2-methylpyridin-3-yloxy) pyridin-3-yl carbamoyl] indoline (SB242084) on penile erections induced by a receptor agonist, 10, 11-dihydroxyaporphine (apomorphine), or a melanocortin receptor agonist, melanotan-II (MT-II) in rats. |
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| 15582454 | Chu W, Tu Z, McElveen E, Xu J, Taylor M, Luedtke RR, Mach RH: Synthesis and in vitro binding of N-phenyl piperazine analogs as potential D3 receptor ligands. Bioorg Med Chem. 2005 Jan 3;13(1):77-87. Binding studies were also conducted to determine if the compounds bound to sigma (sigma (1) and sigma (2)) and (5-HT (1A), 5-HT (2A), 5-HT (2B), 5-HT (2C), 5-HT (3), 5-HT (4), 5-HT (5), 5-HT (6), and 5-HT (7)) receptors. |
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| 11856898 | Gleason SD, Lucaites VL, Shannon HE, Nelson DL, Leander JD: m-CPP hypolocomotion is selectively antagonized by compounds with high affinity for 5-HT (2C) receptors but not 5-HT (2A) or 5-HT (2B) receptors. Behav Pharmacol. 2001 Dec;12(8):613-20. The ability of m-CPP [1-(m-chlorophenyl) piperazine] to produce hypolocomotion is well documented. We investigated the effects of the selective 5-HT (2A) antagonists, MDL 100,907 and ketanserin, the selective 5-HT (2B) antagonists, LY 202146 and LY 266097, the 5-HT (2B/2C) antagonist, SB 206553, and the selective 5-HT (2C) antagonist, SB 242084 on m-CPP-induced hypolocomotion and spontaneous locomotor activity in mice. |
1(0,0,0,1) | Details |
| 11448452 | Porter RH, Malcolm CS, Allen NH, Lamb H, Revell DF, Sheardown MJ: Agonist-induced functional desensitization of recombinant human 5-HT2 receptors expressed in CHO-K1 cells. Biochem Pharmacol. 2001 Aug 15;62(4):431-8. The desensitization characteristics of recombinant human 5-HT (2A), 5-HT (2B), and 5-HT (2C) receptors (VSV and INI isoforms) stably expressed in CHO-K1 (Chinese hamster ovary) cells was investigated by fluorimetry. |
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| 17935799 | Nunes-de-Souza V, Nunes-de-Souza RL, Rodgers RJ, Canto-de-Souza A: 5-HT2 receptor activation in the midbrain periaqueductal grey (PAG) reduces anxiety-like behaviour in mice. Behav Brain Res. 2008 Feb 11;187(1):72-9. Epub 2007 Aug 30. Experiment 1 assessed the effects of intra-PAG infusions of the 5-HT2B/2C receptor agonist mCPP (0, 0.03, 0.1 or 0.3 nmol/0.1 microl) on the behaviour of mice exposed to the elevated plus-maze. |
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| 17207863 | Cornelio AM, Nunes-de-Souza RL: Anxiogenic-like effects of mCPP microinfusions into the amygdala (but not dorsal or ventral hippocampus) in mice exposed to elevated plus-maze. Behav Brain Res. 2007 Mar 12;178(1):82-9. Epub 2007 Jan 17. The present study investigated the effects of the 5-HT (2B/2C) receptor agonist mCPP bilaterally microinjected into the dorsal hippocampus (DH: 0, 0.3, 1.0 or 3.0nmol/0.2microl), the ventral hippocampus (VH: 0, 0.3, 1.0 or 3.0nmol/0.2microl) or the amygdaloid complex (0, 0.15, 0.5, 1.0 or 3.0nmol/0.1microl) in mice exposed to the elevated plus-maze (EPM). |
1(0,0,0,1) | Details |
| 11595362 | Houston GC, Papadakis NG, Carpenter TA, Hall LD, Mukherjee B, James MF, Huang CL: Mapping of brain activation in response to pharmacological agents using fMRI in the rat. Magn Reson Imaging. 2001 Sep;19(7):905-19. The effects of dizocilpine (MK-801) an N-methyl-D-aspartate receptor antagonist and m-chlorophenylpiperazine (mCPP), a 5-HT (2b/2c)-receptor agonist on rat brain activity were investigated over a time interval of about 1 h and the results were compared to published utilisation and cerebral blood flow data. |
1(0,0,0,1) | Details |
| 12798279 | Graf M, Kantor S, Anheuer ZE, Modos EA, Bagdy G: m-CPP-induced self-grooming is mediated by 5-HT2C receptors. . Behav Brain Res. 2003 Jun 16;142(1-2):175-9. To characterise the possible role, 5-HT (2B) and 5-HT (2C) receptors play in m-CPP-induced self-grooming, subtype-selective receptor antagonists were used. m-CPP significantly increased the amount of self-grooming in male Sprague-Dawley rats. |
1(0,0,0,1) | Details |
| 12585687 | Meneses A: Involvement of 5-HT (2A/2B/2C) receptors on memory formation: simple agonism, antagonism, or inverse agonism?. Cell Mol Neurobiol. 2002 Dec;22(5-6):675-88. However, both drugs significantly and differentially antagonized the memory impairments induced by 1-(3-chlorophenyl) piperazine (mCPP), 1-naphtyl-piperazine (1-NP), mesulergine, or N-(3-trifluoromethylphenyl) piperazine (TFMPP). 3. It is suggested that 5-HT (2B/2C) receptors might be involved on memory formation probably mediating a suppressive or constraining action. |
1(0,0,0,1) | Details |