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Chan C, Sandhu J, Guha A, Scollard DA, Wang J, Chen P, Bai K, Lee L, Reilly RM: A human transferrin-vascular endothelial growth factor (hnTf-VEGF) fusion protein containing an integrated binding site for (111) In for imaging tumor angiogenesis. J Nucl Med. 2005 Oct;46(10):1745-52.
The growth-stimulatory effects of hnTf-VEGF on human umbilical vascular endothelial cells (HUVECs) and its binding to porcine aortic endothelial cells (PAECs) transfected with VEGF receptors were evaluated. hnTf-VEGF protein was labeled with (111) InCl (3) in 10 mmol/L HEPES/15 mmol/L NaHCO (3) buffer, pH 7.4 (HEPES is N-(2-hydroxyethyl) piperazine-N'-(2-ethanesulfonic acid). |
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