| Name | estrogen receptors |
|---|---|
| Synonyms | ER; ERA; ER alpha; ERalpha; ESR; ESR 1; ESR1; ESRA… |
| Name | endosulfan |
|---|---|
| CAS | 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin 3-oxide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11884232 | Andersen HR, Vinggaard AM, Rasmussen TH, Gjermandsen IM, Bonefeld-Jorgensen EC: Effects of currently used pesticides in assays for estrogenicity, androgenicity, and aromatase activity in vitro. Toxicol Appl Pharmacol. 2002 Feb 15;179(1):1-12. Twenty-four pesticides were tested for interactions with the estrogen receptor (ER) and the androgen receptor (AR) in transactivation assays. Pesticides (endosulfan, methiocarb, methomyl, pirimicarb, propamocarb, deltamethrin, fenpropathrin, dimethoate, chlorpyriphos, dichlorvos, tolchlofos-methyl, vinclozolin, iprodion, fenarimol, prochloraz, fosetyl-aluminum, chlorothalonil, daminozid, paclobutrazol, chlormequat chlorid, and ethephon) were selected according to their frequent use in Danish greenhouses. |
1(0,0,0,1) | Details |
| 10667634 | Arcaro KF, Yang Y, Vakharia DD, Gierthy JF: Toxaphene is antiestrogenic in a human breast-cancer cell assay. J Toxicol Environ Health A. 2000 Feb 11;59(3):197-210. Toxaphene was also tested for its ability (1) to bind the estrogen receptor (ER) in a competitive binding assay using recombinant human ERalpha (rhER) and in a whole-cell competitive ER binding assay, and (2) to alter the catabolism of E2 in MCF-7 cell cultures. Results from the MCF-7 focus assay showed: (1) Toxaphene alone was not estrogenic between the concentrations of 0.5 nM and 10 microM, (2) toxaphene in binary combinations with chlordane, dieldrin, or endosulfan (alpha or beta) was not estrogenic, and (3) toxaphene was weakly antiestrogenic (it reduced the number of foci induced by 0.1 nM and 0.01 nM E2). |
1(0,0,0,1) | Details |
| 9860891 | Gaido K, Dohme L, Wang F, Chen I, Blankvoort B, Ramamoorthy K, Safe S: Comparative estrogenic activity of wine extracts and organochlorine pesticide residues in food. Environ Health Perspect. 1998 Dec;106 Suppl 6:1347-51. The reconstituted organochlorine mixture contained 1,1,1-trichloro-2-(p-chlorophenyl)-2-(o-chlorophenyl) ethane, 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane, 1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene, endosulfan-1, endosulfan-2, p,p'-methoxychlor, and toxaphene; the relative proportion of each chemical in the mixture resembled the composition reported in a recent U.S. The following battery of in vitro 17 (E2)-responsive bioassays were utilized in this study: competitive binding to mouse uterine estrogen receptor (ER); proliferation in T47D human breast cancer cells; luciferase (Luc) induction in human HepG2 cells transiently cotransfected with C3-Luc and the human ER, rat ER-alpha, or rat ER-beta; induction of chloramphenicol acetyltransferase (CAT) activity in MCF-7 human breast cancer cells transfected with E2-responsive cathepsin D-CAT or kinase B-CAT plasmids. |
1(0,0,0,1) | Details |
| 19590685 | Zhu Z, Edwards RJ, Boobis AR: Increased expression of histone proteins during -mediated cell proliferation. Environ Health Perspect. 2009 Jun;117(6):928-34. Epub 2009 Feb 7. METHODS: In the search for biomarkers, we assessed the effect of several estrogenic compounds on the expression profile of proteins in breast-derived cell lines varying in their estrogen receptor (ER) phenotype using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry. RESULTS: The estrogenic compounds 17beta- bisphenol A, and endosulfan produced similar protein profile changes in MCF-7 cells (phenotype: ERalpha (+)/ERbeta (+)), but had no effect on MDA-MB-231 (ERalpha (-)/ERbeta (+)), MCF-10F (ERalpha (-)/ERbeta (+)), or MCF-10A (ERalpha (-)/ERbeta (-)) cells. |
1(0,0,0,1) | Details |
| 18400491 | Wu F, Khan S, Wu Q, Barhoumi R, Burghardt R, Safe S: Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens. J Steroid Biochem Mol Biol. 2008 May;110(1-2):104-15. Epub 2008 Feb 23. This study investigated the effects of E2, diethylstilbestrol (DES), antiestrogens, the phytoestrogen and the xenoestrogens octylphenol (OP), nonylphenol (NP), endosulfan, kepone, 2,3,4,5-tetrachlorobiphenyl-4-ol (HO-PCB-Cl (4)), bisphenol-A (BPA), and 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) on induction of luciferase activity in breast cancer cells transfected with a construct (pSp1 (3)) containing three tandem GC-rich Sp binding sites linked to luciferase and wild-type or variant ERalpha. |
34(0,1,1,4) | Details |
| 16413991 | Li X, Zhang S, Safe S: Activation of kinase pathways in MCF-7 cells by 17beta- and structurally diverse estrogenic compounds. J Steroid Biochem Mol Biol. 2006 Feb;98(2-3):122-32. Epub 2006 Jan 18. The compounds investigated in this study include E2, diethylstilbestrol (DES), the phytoestrogen and the following synthetic xenoestrogens, bisphenol-A (BPA), nonylphenol, octylphenol, endosulfan, kepone, 2,2-bis (p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE), and 2',3',4',5'-tetrachloro-4-biphenylol (HO-PCB-Cl (4)). These results demonstrate that activation of estrogen receptor-alpha-mediated non-genomic pathways by estrogenic compounds in MCF-7 cells is structure-dependent and can result in activation or inhibition of kinase activities. |
1(0,0,0,1) | Details |
| 11358810 | Coumoul X, Diry M, Robillot C, Barouki R: Differential regulation of cytochrome P450 1A1 and 1B1 by a combination of dioxin and pesticides in the breast tumor cell line MCF-7. Cancer Res. 2001 May 15;61(10):3942-8. Here we show that in MCF-7 cells, 17beta- and alpha-endosulfan can repress whole cell ethoxyresorufin-O-deethylase activity, lowering CYP1A1 mRNA levels as well as promoter activity as assessed by transient transfection assays. |
0(0,0,0,0) | Details |
| 18790044 | Varayoud J, Monje L, Bernhardt T, Munoz-de-Toro M, Luque EH, Ramos JG: Endosulfan modulates -dependent genes like a non-uterotrophic dose of 17beta- Reprod Toxicol. 2008 Oct;26(2):138-45. Epub 2008 Aug 23. PR, ERalpha and C3 expression levels were modified in most of the endosulfan-treated groups, showing an identical pattern of expression to the NUE (2)-group. |
83(1,1,1,3) | Details |
| 12030773 | Rousseau J, Cossette L, Grenier S, Martinoli MG: Modulation of prolactin expression by xenoestrogens. Gen Comp Endocrinol. 2002 Apr;126(2):175-82. Together, our results suggest that endosulfan and chlordane could indeed modulate an -inducible gene such as PRL, possibly acting via second messenger-mediated cellular mechanisms instead of solely competing with estrogens for the nuclear estrogen receptor sites. |
81(1,1,1,1) | Details |
| 11780963 | Murono EP, Derk RC, de Leon JH: Differential effects of octylphenol, 17beta- endosulfan, or bisphenol A on the steroidogenic competence of cultured adult rat Leydig cells. Reprod Toxicol. 2001 Sep-Oct;15(5):551-60. |
0(0,0,0,0) | Details |
| 15589975 | Lemaire G, Balaguer P, Michel S, Rahmani R: Activation of receptor-dependent transcription by organochlorine pesticides. Toxicol Appl Pharmacol. 2005 Jan 1;202(1):38-49. Five organochlorine pesticides, namely, chlordane, dieldrin, aldrin, endrin, and endosulfan, activate human receptor (RAR)-mediated gene transcription via a response element (RARE). |
0(0,0,0,0) | Details |
| 9075711 | Ramamoorthy K, Wang F, Chen IC, Norris JD, McDonnell DP, Leonard LS, Gaido KW, Bocchinfuso WP, Korach KS, Safe S: Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism. Endocrinology. 1997 Apr;138(4):1520-7. Treatment with 10 (-6)-10 (-4) M chlordane, dieldrin, toxaphene, or an equimolar mixture of dieldrin/toxaphene did not induce activity, whereas 10 (-4) M endosulfan caused a 2000-fold increase in beta-gal activity. |
0(0,0,0,0) | Details |
| 15081833 | Gale WL, Patino R, Maule AG: Interaction of xenobiotics with estrogen receptors alpha and beta and a putative plasma sex hormone-binding globulin from channel catfish (Ictalurus punctatus). Gen Comp Endocrinol. 2004 May 1;136(3):338-45. The alkylphenolic compounds (4-octylphenol and 4-nonylphenol) displayed some ability to displace 3H-E2 binding from ERalpha and beta at high concentrations, but dieldrin and atrazine had little binding activity for both ER subtypes and endosulfan for ERbeta. |
34(0,1,1,4) | Details |
| 15811834 | Wozniak AL, Bulayeva NN, Watson CS: Xenoestrogens at picomolar to nanomolar concentrations trigger membrane estrogen receptor-alpha-mediated Ca2+ fluxes and prolactin release in GH3/B6 pituitary tumor cells. Environ Health Perspect. 2005 Apr;113(4):431-9. We investigated the effects of E2 versus several XEs representing organochlorine pesticides (dieldrin, endosulfan, o',p'-dichlorodiphenylethylene), plastics manufacturing by-products/detergents (nonylphenol, bisphenol A), a phytoestrogen (coumestrol), and a synthetic (diethylstilbestrol) on the pituitary tumor cell subline GH3/B6/F10, previously selected for expression of high levels of membrane estrogen receptor-alpha. |
32(0,1,1,2) | Details |
| 9407589 | Wade MG, Desaulniers D, Leingartner K, Foster WG: Interactions between endosulfan and dieldrin on -mediated processes in vitro and in vivo. Reprod Toxicol. 1997 Nov-Dec;11(6):791-8. Recent in vitro data suggest that the interaction between some weakly estrogenic organochlorines, dieldrin, endosulfan, toxaphene, and chlordane, causes a synergistic increase in their estrogenic potency, an effect due to joint action on estrogen receptors (ER). |
31(0,1,1,1) | Details |
| 12601910 | Chang Y, Zhu XQ, Zhu HJ, Zheng YF, Huang XS: [Assessment of the estrogenicity of endosulfan and other chemicals with the in vitro proliferation of human breast cancer cell]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2002 Aug;31(4):281-283. It was found that diethylstilbestrol was a full agonist of estrogen receptor, endosulfan was a partial agonist, while 4 hydrotamoxifen lacked estrogenic effects at this assay. |
31(0,1,1,1) | Details |
| 17174995 | Watson CS, Bulayeva NN, Wozniak AL, Alyea RA: Xenoestrogens are potent activators of nongenomic estrogenic responses. Steroids. 2007 Feb;72(2):124-34. Epub 2006 Dec 18. Both (E (2)) and compounds representing various classes of xenoestrogens (diethylstilbestrol, coumestrol, bisphenol A, DDE, nonylphenol, endosulfan, and dieldrin) act via a membrane version of the estrogen receptor-alpha on pituitary cells, and can provoke Ca (2+) influx via L-type channels, leading to prolactin (PRL) secretion. |
31(0,1,1,1) | Details |
| 15832825 | Je KH, Kim KN, Nam KW, Cho MH, Mar W: TERT mRNA expression is up-regulated in MCF-7 cells and a mouse mammary organ culture (MMOC) system by endosulfan treatment. Arch Pharm Res. 2005 Mar;28(3):351-7. Telomerase can be activated by therefore, we examined the effects of endosulfan on telomerase activity, and found that the telomerase activity in estrogen receptor-positive MCF-7 cells was up-regulated by endosulfan treatment. |
31(0,1,1,1) | Details |
| 15261991 | Grunfeld HT, Bonefeld-Jorgensen EC: Effect of in vitro estrogenic pesticides on human oestrogen receptor alpha and beta mRNA levels. Toxicol Lett. 2004 Aug 1;151(3):467-80. Endosulfan and pirimicarb alone decreased the ERalpha mRNA level weakly. |
11(0,0,1,6) | Details |
| 19479021 | Alyea RA, Watson CS: Differential regulation of dopamine transporter function and location by low concentrations of environmental estrogens and 17beta- Environ Health Perspect. 2009 May;117(5):778-83. Epub 2009 Jan 5. OBJECTIVE: We examined low concentrations of XEs [dieldrin, endosulfan, o', p'-dichlorodiphenyl-ethylene (DDE), nonylphenol (NP), and bisphenol A (BPA)] for nongenomic actions via action of membrane estrogen receptors (ERs). |
8(0,0,1,3) | Details |
| 12735107 | Larkin P, Folmar LC, Hemmer MJ, Poston AJ, Denslow ND: Expression profiling of estrogenic compounds using a sheepshead minnow cDNA macroarray. EHP Toxicogenomics. 2003 Jan;111(1T):29-36. Endosulfan produced results that resembled the gene expression patterns of untreated control fish with exception of the upregulation of estrogen receptor alpha and the downregulation of a cDNA clone that shares similarity to 3-hydroxy-3-methylglutaryl-coenzyme A reductase. |
7(0,0,1,2) | Details |
| 16626760 | Lemaire G, Mnif W, Mauvais P, Balaguer P, Rahmani R: Activation of alpha- and beta-estrogen receptors by persistent pesticides in reporter cell lines. Life Sci. 2006 Aug 15;79(12):1160-9. Epub 2006 Mar 27. Antagonistic activities toward hERalpha and hERbeta were shown in three (carbaryl, pentachlorophenol and 2,4,5-trichlorophenoxyacetic acid) and seven (chlordecone, methoxychlor, carbaryl, endosulfan, endrin, dieldrin, aldrin) pesticides, respectively. |
6(0,0,0,6) | Details |
| 10330684 | Legler J, van den Brink CE, Brouwer A, Murk AJ, van der Saag PT, Vethaak AD, van der Burg B: Development of a stably transfected estrogen receptor-mediated luciferase reporter gene assay in the human T47D breast cancer cell line. Toxicol Sci. 1999 Mar;48(1):55-66. Determination of interactive effects of the (pseudo-) estrogens nonylphenol, o,p'DDT, chlordane, endosulfan, dieldrin, and methoxychlor revealed that, in combination with 3 pM E2, (pseudo-) estrogens were additive. |
3(0,0,0,3) | Details |
| 8633243 | Arnold SF, Klotz DM, Collins BM, Vonier PM, Guillette LJ Jr, McLachlan JA: Synergistic activation of estrogen receptor with combinations of environmental chemicals. Science. 1996 Jun 7;272(5267):1489-92. Combinations of two weak environmental estrogens, such as dieldrin, endosulfan, or toxaphene, were 1000 times as potent in hER-mediated transactivation as any chemical alone. |
3(0,0,0,3) | Details |
| 9460653 | Petit F, Le Goff P, Cravedi JP, Valotaire Y, Pakdel F: Two complementary bioassays for screening the estrogenic potency of xenobiotics: recombinant yeast for trout estrogen receptor and trout hepatocyte cultures. J Mol Endocrinol. 1997 Dec;19(3):321-35. In our study, 50% of the 49 chemical compounds tested exhibited estrogenic activity in the two bioassays: the herbicide diclofop-methyl; the fungicides biphenyl, dodemorph, and triadimefon; the insecticides lindane, methyl parathion, chlordecone, dieldrin, and endosulfan; polychlorinated biphenyl mixtures; the plasticizers or detergents alkylphenols and phthalates; and phytoestrogens. |
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| 11162928 | Matthews J, Celius T, Halgren R, Zacharewski T: Differential estrogen receptor binding of a species comparison. J Steroid Biochem Mol Biol. 2000 Nov 15;74(4):223-34. Methoxychlor, p,p'-DDT, o,p'-DDE, p,p'-DDE, alpha-endosulfan and dieldrin weakly bound to the ERs from the human, mouse, chicken and green anole. |
2(0,0,0,2) | Details |
| 10397250 | Hunter DS, Hodges LC, Vonier PM, Fuchs-Young R, Gottardis MM, Walker CL: Estrogen receptor activation via activation function 2 predicts agonism of xenoestrogens in normal and neoplastic cells of the uterine myometrium. Cancer Res. 1999 Jul 1;59(13):3090-9. Diethylstilbestrol, coumestrol, and endosulfan were able to activate the AF2 function of the ER in vitro and demonstrated agonist activity in -responsive myometrial cells, as determined by induction of proliferation and increased message levels of progesterone receptor. |
2(0,0,0,2) | Details |
| 15531431 | Bulayeva NN, Watson CS: Xenoestrogen-induced ERK-1 and ERK-2 activation via multiple membrane-initiated signaling pathways. Environ Health Perspect. 2004 Nov;112(15):1481-7. Xenoestrogens can mimic or antagonize the activity of physiological estrogens, and the suggested mechanism of xenoestrogen action involves binding to estrogen receptors (ERs). We tested a phytoestrogen (coumestrol), organochlorine pesticides or their metabolites (endosulfan, dieldrin, and DDE), and detergent by-products of plastics manufacturing (p-nonylphenol and bisphenol A). |
2(0,0,0,2) | Details |
| 17366818 | Narita S, Goldblum RM, Watson CS, Brooks EG, Estes DM, Curran EM, Midoro-Horiuti T: Environmental estrogens induce mast cell degranulation and enhance IgE-mediated release of allergic mediators. Environ Health Perspect. 2007 Jan;115(1):48-52. We incubated a human mast cell line and primary mast cell cultures derived from bone marrow of wild type and estrogen receptor alpha (ER-alpha)-deficient mice with environmental estrogens with and without or IgE and allergens. |
2(0,0,0,2) | Details |
| 16242299 | Wong PS, Matsumura F: Serum free BG-1 cell proliferation assay: a sensitive method for determining organochlorine pesticide estrogen receptor activation at the nanomolar range. Toxicol In Vitro. 2006 Apr;20(3):382-94. Epub 2005 Oct 19. We observed concentration dependent ER mediated cell proliferation in BG-1 cells using heptachlor epoxide (HE), beta-hexachlorohexane (beta-HCH), and endosulfan (Endo). |
2(0,0,0,2) | Details |
| 14975756 | Sekine Y, Yamamoto T, Yumioka T, Imoto S, Kojima H, Matsuda T: Cross-talk between endocrine-disrupting chemicals and cytokine signaling through estrogen receptors. Biochem Biophys Res Commun. 2004 Mar 12;315(3):692-8. |
2(0,0,0,2) | Details |
| 10229711 | Andersen HR, Andersson AM, Arnold SF, Autrup H, Barfoed M, Beresford NA, Bjerregaard P, Christiansen LB, Gissel B, Hummel R, Jorgensen EB, Korsgaard B, Le Guevel R, Leffers H, McLachlan J, Moller A, Nielsen JB, Olea N, Oles-Karasko A, Pakdel F, Pedersen KL, Perez P, Skakkeboek NE, Sonnenschein C, Soto AM, et al.: Comparison of short-term estrogenicity tests for identification of hormone-disrupting chemicals. Environ Health Perspect. 1999 Feb;107 Suppl 1:89-108. Test methods included direct binding to the estrogen receptor (ER), proliferation of MCF-7 cells, transient reporter gene expression in MCF-7 cells, reporter gene expression in yeast strains stably transfected with the human ER and an -responsive reporter gene, and vitellogenin production in juvenile rainbow trout. 17beta- 17alpha-ethynyl and diethylstilbestrol induced a strong estrogenic response in all test systems. The results obtained for the remaining test compounds--tamoxifen, ICI 182.780, bisphenol A dimethacrylate, 4-n-octylphenol, 4-n-nonylphenol, nonylphenol dodecylethoxylate, butylbenzylphthalate, dibutylphthalate, methoxychlor, o,p'-DDT, p,p'-DDE, endosulfan, chlomequat and --varied among the assays. |
1(0,0,0,1) | Details |
| 11689155 | Washington W, Hubert L, Jones D, Gray WG: Bisphenol a binds to the low-affinity binding site. In Vitr Mol Toxicol. 2001 Spring;14(1):43-51. The influences of these compounds have been proposed to be mediated through binding to macromolecules, such as estrogen receptor alpha or beta. The binding of BPA to Type II EBS appeared specific to BPA, in that endosulfan, another environmental failed to displace from the site. |
2(0,0,0,2) | Details |
| 9703490 | Arcaro KF, Vakharia DD, Yang Y, Gierthy JF: Lack of synergy by mixtures of weakly estrogenic hydroxylated polychlorinated biphenyls and pesticides. Environ Health Perspect. 1998 Aug;106 Suppl 4:1041-6. We examined the estrogenicity of binary mixtures of the hydroxylated polychlorinated biphenyls (OHPCBs) 2,4,6-trichloro-4'-biphenylol (2,4,6-TCB-4'-OH) and 2,3,4,5-tetrachloro-4'-biphenylol and the pesticides endosulfan and dieldrin. The OHPCBs and pesticides were tested in both the MCF-7 focus assay and a competitive estrogen-receptor binding assay. |
2(0,0,0,2) | Details |
| 9118873 | Vonier PM, Crain DA, McLachlan JA, Guillette LJ Jr, Arnold SF: Interaction of environmental chemicals with the and progesterone receptors from the oviduct of the American alligator. Environ Health Perspect. 1996 Dec;104(12):1318-22. To determine whether environmental chemicals had the potential to function as exogenous hormones in the American alligator, we examined the ability of chemicals to bind the estrogen receptor (aER) and progesterone receptor (aPR) in a protein extract prepared from the oviduct of the alligator. Modern-use chemicals such as alachlor, trans-nonachlor, endosulfan, and atrazine also competed with [3H] 17 beta- for binding to the aER. |
1(0,0,0,1) | Details |
| 12450323 | Cossette LJ, Gaumond I, Martinoli MG: Combined effect of xenoestrogens and growth factors in two -responsive cell lines. Endocrine. 2002 Aug;18(3):303-8. Several crosstalks between the estrogen receptor and other signaling pathways may influence the estrogenic stimulation of cell growth. Cells were treated with two known xenoestrogens, endosulfan and chlordane, alone or in the presence of insulin-like growth factor-1 and epidermal growth factor, respectively, and their growth was measured using the 2,3-bis (2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxyanilide proliferation assay. |
1(0,0,0,1) | Details |
| 16219411 | Bonefeld-Jorgensen EC, Grunfeld HT, Gjermandsen IM: Effect of pesticides on estrogen receptor transactivation in vitro: a comparison of stable transfected MVLN and transient transfected MCF-7 cells. Mol Cell Endocrinol. 2005 Dec 1;244(1-2):20-30. Epub 2005 Oct 10. The estrogenic potential of four pesticides (endosulfan, prochloraz, tolchlofos-methyl and propamocarb) was compared in parallel with 17beta- (E2) by reporter constructs in transient transfected MCF-7BUS and in stable transfected MVLN cells. |
1(0,0,0,1) | Details |
| 19478717 | Roy JR, Chakraborty S, Chakraborty TR: -like endocrine disrupting chemicals affecting puberty in humans--a review. Med Sci Monit. 2009 Jun;15(6):RA137-45. The structural similarity of disruptors with allow them to bind and activate estrogen receptors and show a similar response even in the absence of that can lead to precocious puberty (PP). Major EEDCs found abundantly in our environment include; dichlorodiphenyltrichloroethane (DDT), dioxin, polychlorinated biphenyls (PCBs), bisphenol A (BPA), polybrominated biphenyls (PBB), esters, endosulfan, atrazine and zeranol. |
1(0,0,0,1) | Details |
| 10774817 | Hodges LC, Bergerson JS, Hunter DS, Walker CL: Estrogenic effects of organochlorine pesticides on uterine leiomyoma cells in vitro. Toxicol Sci. 2000 Apr;54(2):355-64. These data demonstrate that organochlorine pesticides act as estrogen receptor agonists in Eker rat uterine myometrial cells, and they indicate a need for further investigation of the potential tissue-specific agonist activity of these pesticides and their role in the pathogenesis of uterine leiomyoma. In Eker rat leiomyoma-derived cells, HPTE, kepone, and the alpha isomer of endosulfan stimulated proliferation, an effect dampened by the antiestrogen ICI 182,780. |
1(0,0,0,1) | Details |
| 16797915 | Vanparys C, Maras M, Lenjou M, Robbens J, Van Bockstaele D, Blust R, De Coen W: Flow cytometric cell cycle analysis allows for rapid screening of estrogenicity in MCF-7 breast cancer cells. Toxicol In Vitro. 2006 Oct;20(7):1238-48. Epub 2006 May 16. This flow cytometric proliferation assay confirms that the estrogenic activity of structurally analogous parabens is mediated by the estrogen receptor pathway and is proportional to the alkyl chain length. |
1(0,0,0,1) | Details |
| 9118870 | Shelby MD, Newbold RR, Tully DB, Chae K, Davis VL: Assessing environmental chemicals for estrogenicity using a combination of in vitro and in vivo assays. Environ Health Perspect. 1996 Dec;104(12):1296-300. The assays were 1) competitive binding with the mouse uterine estrogen receptor, 2) transcriptional activation in HeLa cells transfected with plasmids containing an estrogen receptor and a response element, and 3) the uterotropic assay in mice. The chemicals studied were 17 beta- diethylstilbestrol, tamoxifen, 4-hydroxytamoxifen, methoxychlor, the methoxychlor metabolite 2,2-bis (p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE), endosulfan, nonylphenol, o,p'-DDT, and kepone. |
1(0,0,0,1) | Details |
| 16896612 | Dhooge W, Arijs K, D'Haese I, Stuyvaert S, Versonnen B, Janssen C, Verstraete W, Comhaire F: Experimental parameters affecting sensitivity and specificity of a yeast assay for estrogenic compounds: results of an interlaboratory validation exercise. Anal Bioanal Chem. 2006 Nov;386(5):1419-28. Epub 2006 Aug 3. One out of the three laboratories did not classify alpha,beta-endosulfan, dissolved in DMSO, as an Therefore it fulfills the requirements as a first step screening assay to evaluate the capacity of chemicals to interact with the estrogen receptor. |
1(0,0,0,1) | Details |
| 8593856 | Soto AM, Sonnenschein C, Chung KL, Fernandez MF, Olea N, Serrano FO: The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants. Environ Health Perspect. 1995 Oct;103 Suppl 7:113-22. Among the compounds tested, several "new" estrogens were found; alkylphenols, phthalates, some PCB congeners and hydroxylated PCBs, and the insecticides dieldrin, endosulfan, and toxaphene were estrogenic by the E-SCREEN assay. In addition, these compounds competed with for binding to the estrogen receptor and increased the levels of progesterone receptor and pS2 in MCF-7 cells, as expected from mimics. |
1(0,0,0,1) | Details |