| Name | protein kinase A (protein family or complex) |
|---|---|
| Synonyms | Protein kinase A; cAMP dependent protein kinase; cAMP dependent protein kinases |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15680943 | Zsombok A, Schrofner S, Hermann A, Kerschbaum HH: A -dependent cascade enhances an L-type-like Ca2+ current in identified snail neurons. Brain Res. 2005 Jan 25;1032(1-2):70-6. Blockade of protein kinase activity with 1-[5-isoquinolinesulfonyl]-2 methyl piperazine (H 7), a nonselective protein kinase inhibitor, or Rp-8-pCPT- a selective protein kinase G (PKG) inhibitor, decreased, whereas Rp-cAMP, a selective protein kinase A (PKA) inhibitor, increased the Ba (2+) current upon application of analogues or SNP. |
31(0,1,1,1) | Details |
| 12211084 | Thumen A, Qadri F, Sarkar R, Moser A: GBR-12909 effect on outflow depends on phosphorylation in the caudate nucleus of the rat. Synapse. 2002 Nov;46(2):72-8. Activation of protein kinase A and C markedly enhanced the effect of GBR-12909, whereas protein kinase inhibition by H7 reduced the GBR-12909 effect. These results suggest a complex and strong influence of phosphorylation on GBR-12909 effects on calcium channel-dependent DA outflow at low-affinity piperazine binding sites in slices of the rat caudate nucleus in vitro. |
1(0,0,0,1) | Details |
| 17141281 | Dong LY, Cheng ZX, Fu YM, Wang ZM, Zhu YH, Sun JL, Dong Y, Zheng P: Neurosteroid enhances spontaneous release in rat prelimbic cortex through activation of D1 and sigma-1 receptor. Neuropharmacology. 2007 Mar;52(3):966-74. Epub 2006 Nov 30. The results showed that increased the frequency of miniature excitatory postsynaptic currents in the prelimbic cortex and hippocampus; sigma-1 receptor antagonist partially blocked the effect of in the prelimbic cortex, but completely blocked it in the hippocampus; D1 receptor antagonist, adenylyl cyclase inhibitor and protein kinase A inhibitor completely blocked the effect of in the prelimbic cortex; increased the activity of protein kinase A in the prelimbic cortex and hippocampus; the effect of on protein kinase A was completely blocked by sigma-1 receptor antagonist in the hippocampus, but was partially blocked in the prelimbic cortex; interestingly, here again, the effect of on protein kinase A was completely blocked by D1 receptor antagonist in the prelimbic cortex. |
1(0,0,0,1) | Details |
| 20164327 | Zhang J, Huang XY, Ye ML, Luo CX, Wu HY, Hu Y, Zhou QG, Wu DL, Zhu LJ, Zhu DY: Neuronal nitric oxide synthase alteration accounts for the role of 5-HT1A receptor in modulating anxiety-related behaviors. J Neurosci. 2010 Feb 17;30(7):2433-41. Blockade of hippocampal CREB phosphorylation by microinjection of H89 (5.19 microg/1.0 microl), a PKA (protein kinase A) inhibitor, abolished the anxiolytic-like effects of 7-NI (i.p., 30 mg/kg/d for 21 d). |
1(0,0,0,1) | Details |
| 12417643 | Wang X, Zhong P, Yan Z: Dopamine D4 receptors modulate GABAergic signaling in pyramidal neurons of prefrontal cortex. J Neurosci. 2002 Nov 1;22(21):9185-93. To understand the cellular mechanisms and functional implications of D4 receptors, we examined the impact of D4 receptors in PFC pyramidal neurons on GABAergic inhibition, a key element in the regulation of "working memory." Application of the D4 agonist N-(methyl)-4-(2-cyanophenyl) piperazinyl-3-methylbenzamide caused a reversible decrease in postsynaptic (A) receptor currents; this effect was blocked by the D4 antagonist 3-[(4-[4-chlorophenyl] piperazine-1-yl) methyl]-[1H]-pyrrolo [2,3-b] but not by the D2 antagonist sulpiride, suggesting mediation by D4 receptors. The D4 modulation of (A) receptor currents was blocked by protein kinase A (PKA) activation and occluded by PKA inhibition. |
1(0,0,0,1) | Details |
| 15456534 | Zhang XF, Guo SZ, Lu KH, Li HY, Li XD, Zhang LX, Yang L: Different roles of PKC and PKA in effect of interferon-gamma on proliferation and collagen synthesis of fibroblasts. Acta Pharmacol Sin. 2004 Oct;25(10):1320-6. The proliferation and collagen synthesis were enhanced by PKC activator (containing diacylglycerol and Ca2+) and PKA inhibitor [H (7) 250 micromol/L, 1-(5-isoquinolinylsulfonyl)-2-methyl piperazine], and inhibited by PKC inhibitor (GF109 250 micromol/L) and PKA activator (cAMP 25 micromol/L) (P <0.01). AIM: To study the signal roles of protein kinase C (PKC) and protein kinase A (PKA) in the influence of interferon-gamma (IFN-gamma) on proliferation and collagen synthesis of fibroblasts derived from hypertrophic scar (HS-FB) and normal skin (NS-FB). |
1(0,0,0,1) | Details |
| 12466248 | Wang SJ, Coutinho V, Sihra TS: Presynaptic cross-talk of beta-adrenoreceptor and 5-hydroxytryptamine receptor signalling in the modulation of release from cerebrocortical nerve terminals. Br J Pharmacol. 2002 Dec;137(8):1371-9. The presynaptic interactions between facilitatory beta-adrenoreceptors and inhibitory receptors modulating release from cerebrocortical nerve terminals were examined. 2. 4-aminopyridine (4-AP, 1 mM)-evoked release was facilitated by the membrane permeant cyclic-3',5'- (cAMP) analogue, 8-bromo-cAMP (8-Br-cAMP), used to directly activate cAMP-dependent protein kinase (PKA). 3. The inhibitory effect of could be mimicked by the selective 5-HT (1A) receptor agonist, 8--dipropylaminotetralin (8-OH-DPAT) and antagonized by 1-(2-methoxyphenyl)-4-(4-phthalimidobutyl) piperazine (NAN-190). 5. |
1(0,0,0,1) | Details |
| 16682960 | Kim HW, Kwon YB, Roh DH, Yoon SY, Han HJ, Kim KW, Beitz AJ, Lee JH: Intrathecal treatment with sigma1 receptor antagonists reduces formalin-induced phosphorylation of NMDA receptor subunit 1 and the second phase of formalin test in mice. Br J Pharmacol. 2006 Jun;148(4):490-8. Epub 2006 May 8. I.t. injection of BD-1047 also reduced formalin-evoked Fos expression and pNR1 at the protein kinase C-dependent site, serine-896 (Ser896) and the protein kinase A-dependent site, serine-897 (Ser897) in spinal dorsal horn.i.t. |
1(0,0,0,1) | Details |
| 17392733 | Lee JJ, Hahm ET, Lee CH, Cho YW: Serotonergic modulation of GABAergic and glutamatergic synaptic transmission in mechanically isolated rat medial preoptic area neurons. Neuropsychopharmacology. 2008 Jan;33(2):340-52. Epub 2007 Mar 28. H-89, a selective protein kinase A (PKA) inhibitor, decreased the frequencies of GABAergic mIPSCs and glutamatergic mEPSCs, and blocked their reduction by Serotonergic inhibition of mIPSC frequency was mimicked by (+/-)-8--2-dipropylaminotetralin hydrobromide, a specific 5-HT (1A) receptor agonist, and blocked by 1-(2-methoxyphenyl)-4-[4-(2-phthalimido) butyl] piperazine hydrobromide, a specific 5-HT (1A) receptor antagonist. 6--7-nitroquinoxaline-2,3-dione completely blocked spontaneous glutamatergic miniature excitatory postsynaptic currents (mEPSCs) in the MPOA. |
1(0,0,0,1) | Details |