| Name | MMP 1 |
|---|---|
| Synonyms | CLG; CLGN; Fibroblast collagenase; Interstitial collagenase; Interstitial collagenase precursor; MMP 1; MMP1; MMP1 protein… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11677139 | Levin JI, Chen JM, Du MT, Nelson FC, Wehr T, DiJoseph JF, Killar LM, Skala S, Sung A, Sharr MA, Roth CE, Jin G, Cowling R, Di L, Sherman M, Xu ZB, March CJ, Mohler KM, Black RA, Skotnicki JS: The discovery of -based MMP inhibitors. Bioorg Med Chem Lett. 2001 Nov 19;11(22):2975-8. derivatives bearing basic amines were prepared and evaluated in vitro and in vivo as inhibitors of MMP-1, MMP-9, MMP-13, and TACE. Piperazine 4u has been identified as a potent, selective, orally active inhibitor of MMP-9 and MMP-13. |
1(0,0,0,1) | Details |
| 12951101 | Letavic MA, Barberia JT, Carty TJ, Hardink JR, Liras J, Lopresti-Morrow LL, Mitchell PG, Noe MC, Reeves LM, Snow SL, Stam EJ, Sweeney FJ, Vaughn ML, Yu CH: Synthesis and biological activity of piperazine-based dual MMP-13 and TNF-alpha converting enzyme inhibitors. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3243-6. The TACE, MMP-1 and MMP-13 activity of these inhibitors as well as the effect of substitution of the piperazine and the P-1' benzyloxy tailpiece is discussed. |
31(0,1,1,1) | Details |