Protein Information

Name mMDH
Synonyms M MDH; MDH; MDH 2; MDH2; MOR1; Malate dehydrogenase; Malate dehydrogenase mitochondrial; mMDH…

Compound Information

Name endosulfan
CAS 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin 3-oxide

Reference List

PubMed Abstract RScore(About this table)
9185323 Mishra R, Shukla SP: Impact of endosulfan on cytoplasmic and mitochondrial liver malate dehydrogenase from the freshwater catfish (Clarias batrachus). Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1997 May;117(1):7-18.

Summarizing, it can be stated that endosulfan exerts an inhibitory effect on crude cMDH and mMDH in vivo, and their purified isoforms (C5-cMDH and M2-mMDH) in vivo as well as in vitro.
183(1,4,5,8) Details
2331326 Tripathi G, Shukla SP: Malate and lactate dehydrogenases of a freshwater catfish: impact of endosulfan. Biomed Environ Sci. 1990 Mar;3(1):52-64.

A sublethal concentration of technical grade endosulfan (END) inhibited 35 to 55% of the activities of cytoplasmic malate dehydrogenase (cMDH), mitochondrial malate dehydrogenase (mMDH), and lactate dehydrogenase (LDH) in the liver and the skeletal muscle of a freshwater catfish, Clarias batrachus, after 7 days of exposure.
82(1,1,1,2) Details
14575683 Mishra R, Shukla SP: Endosulfan effects on muscle malate dehydrogenase of the freshwater catfish Clarias batrachus. Ecotoxicol Environ Saf. 2003 Nov;56(3):425-33.

The inhibition produced by endosulfan in vivo was of mixed noncompetitive/uncompetitive type for crude as well as purified cMDH and mMDH.
40(0,1,2,5) Details