Protein Information

Name beta glucuronidase
Synonyms Beta glucuronidase; Beta G1; Beta glucuronidase precursor; GUSB; MPS 7; MPS7; Beta G1s; Beta glucuronidase precursors

Compound Information

Name piperazine
CAS piperazine

Reference List

PubMed Abstract RScore(About this table)
20005707 Bandgar BP, Patil SA, Gacche RN, Korbad BL, Hote BS, Kinkar SN, Jalde SS: Synthesis and biological evaluation of nitrogen-containing chalcones as possible anti-inflammatory and antioxidant agents. Bioorg Med Chem Lett. 2010 Jan 15;20(2):730-3. Epub 2009 Dec 11.

Overall, the results of the studies reveal that the chalcones with N-methyl piperazine methyl and piperidine methyl substitution (4c, 3b, 4d, 6b) seems to be important for inhibition of beta-glucuronidase.
82(1,1,1,2) Details
14744939 Miller RR, Doss GA, Stearns RA: Identification of a hydroxylamine glucuronide metabolite of an oral hypoglycemic agent. Drug Metab Dispos. 2004 Feb;32(2):178-85.

Glucuronides of piperazine hydroxylamines are rarely reported in the literature, and even more rarely are their structures unambiguously identified.
Treatment with beta-glucuronidase gave a monooxygenated derivative of the parent compound. 1H NMR analysis of either the glucuronic acid conjugate or the monooxygenated product provided insufficient evidence to unambiguously determine their structures.
2(0,0,0,2) Details