| Name | CA III |
|---|---|
| Synonyms | CA III; Carbonic anhydrase C; CA3; CAIII; Car3; Carbonate dehydratase III; Carbonic anhydrase 3; Carbonic anhydrase III… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12941378 | Ayala GX, Tapia R: Expression of heat shock protein 70 induced by 4-aminopyridine through -mediated excitotoxic stress in rat hippocampus in vivo. Neuropharmacology. 2003 Oct;45(5):649-60. The first signs of histological neuronal damage were observed in CA1 and CA3 subfields of the perfused hippocampus 3 h after treatment and progressed until reaching a maximal neuronal loss at 24 h. The (NMDA) receptor antagonists MK-801 and (3-phosphonopropyl)-piperazine-2-carboxylic acid prevented the seizures, the neurodegeneration and the expression of HSP70. |
1(0,0,0,1) | Details |
| 15146049 | Lozovaya NA, Grebenyuk SE, Tsintsadze TSh, Feng B, Monaghan DT, Krishtal OA: Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape 'superslow' afterburst EPSC in rat hippocampus. J Physiol. 2004 Jul 15;558(Pt 2):451-63. Epub 2004 May 14. In conditions of facilitated synaptic release, CA3/CA1 synapses generate anomalously slow NMDA receptor-mediated EPSCs (EPSC In contrast, ifenprodil, a highly selective NR2B antagonist, and [+/-]-cis-1-[phenanthren-2yl-carbonyl] piperazine-2,3-dicarboxylic acid (PPDA), a competitive antagonist that is moderately selective for NR2D subunits, more strongly inhibited the late component of the afterburst EPSC |
1(0,0,0,1) | Details |
| 12166089 | Tsuji K: [Effect of (+/-)-pindolol on the central 5-HT1A receptor by the use of in vivo microdialysis and hippocampal slice preparations]. Nihon Shinkei Seishin Yakurigaku Zasshi. 2002 Jun;22(3):85-95. The and other 5-HT1A receptor agonists, flesinoxan and 8--2- (di-n-propylamino) tetralon (8-OH-DPAT), significantly decreased the population excitatory postsynaptic potential (EPSP) in the CA3-CA1 excitatory synapse in a dose-dependent manner. |
1(0,0,0,1) | Details |
| 19684252 | Costa BM, Feng B, Tsintsadze TS, Morley RM, Irvine MW, Tsintsadze V, Lozovaya NA, Jane DE, Monaghan DT: (NMDA) receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives: preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse. J Pharmacol Exp Ther. 2009 Nov;331(2):618-26. Epub 2009 Aug 14. |
82(1,1,1,2) | Details |
| 11172755 | Inoue T, Wang F, Moriguchi A, Shirakawa K, Matsuoka N, Goto T: FK960, a novel potential anti-dementia drug, enhances high K (+)-evoked release of somatostatin from rat hippocampal slices. Brain Res. 2001 Feb 16;892(1):111-7. We have demonstrated that FK960 [N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate], a novel putative anti-dementia drug of piperazine derivative, ameliorates memory deficits in a variety of animal models of dementia in rats and monkeys, and also augments long-term potentiation (LTP) in the mossy fiber-CA3 pathway in guinea-pig hippocampal slices. |
31(0,1,1,1) | Details |
| 18627905 | Vullo D, Nishimori I, Scozzafava A, Supuran CT: Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4303-7. Epub 2008 Jun 28. An activation study of the human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms hCA III (cytosolic) and IV (membrane-associated) with a series of natural and non-natural amino acids and aromatic/heterocyclic amines is reported. hCA III was efficiently activated by d-His, pyridyl-alkylamines, and aminoethyl-piperazine/morpholine (K (A) s of 91nM-1.12microM), whereas the best hCA IV activators were 4-amino- and 4-(2-aminoethyl)-morpholine (K (A) s of 79nM-3.14microM). Precise steric and electronic requirements are needed to be present in the molecules of effective CA III/IV activators, in order to assure an adequate fit within the enzyme active site for the formation of the enzyme-activator complex, and for efficient transfer processes between the active site and the reaction medium. |
2(0,0,0,2) | Details |