| Name | bcl 2 |
|---|---|
| Synonyms | Apoptosis regulator Bcl 2; B cell CLL/lymphoma 2; B cell lymphoma protein 2 alpha; B cell lymphoma protein 2 alpha isoform; BCL2; Bcl 2; B cell CLL/lymphoma 2s; B cell lymphoma protein 2 alphas… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19143029 | Liu CM, Lo YC, Tai MH, Wu BN, Wu WJ, Chou YH, Chai CY, Huang CH, Chen IJ: Piperazine-designed alpha 1A/alpha 1D-adrenoceptor blocker KMUP-1 and doxazosin provide down-regulation of androgen receptor and PSA in prostatic LNCaP cells growth and specifically in xenografts. Prostate. 2009 May 1;69(6):610-23. Moreover, KMUP-1 activated p53, cleaved poly (ADP- polymerase and caspase-3, but reduced the expression of Bcl-2. |
1(0,0,0,1) | Details |
| 19481059 | Zeng S, Liu W, Nie FF, Zhao Q, Rong JJ, Wang J, Tao L, Qi Q, Lu N, Li ZY, Guo QL: LYG-202, a new with a piperazine substitution, shows antitumor effects in vivo and in vitro. Biochem Biophys Res Commun. 2009 Aug 7;385(4):551-6. Epub 2009 May 27. The results also showed that the expression of Bcl-2 protein decreased whereas that of Bax protein increased, leading to an increase of the Bax/Bcl-2 ratio. |
1(0,0,0,1) | Details |
| 16152590 | Weiderhold KN, Randall-Hlubek DA, Polin LA, Hamel E, Mooberry SL: CB694, a novel antimitotic with antitumor activities. Int J Cancer. 2006 Feb 15;118(4):1032-40. Bcl-2 phosphorylation and activation of ERK and JNK and caspase 3-dependent cleavage of PARP were observed in MDA-MB-435 cells treated with CB694. During the course of a mechanism-based screening program aimed at identifying new antimitotic agents, a novel microtubule depolymerizing piperazine derivative, 1-(5-chloro-2-methoxybenzoyl)-4-(3-chlorophenyl) piperazine, was identified. |
1(0,0,0,1) | Details |
| 19218529 | Wisel S, Khan M, Kuppusamy ML, Mohan IK, Chacko SM, Rivera BK, Sun BC, Hideg K, Kuppusamy P: Pharmacological preconditioning of mesenchymal stem cells with trimetazidine (1-[2,3,4-trimethoxybenzyl] piperazine) protects hypoxic cells against oxidative stress and enhances recovery of myocardial function in infarcted heart through Bcl-2 expression. J Pharmacol Exp Ther. 2009 May;329(2):543-50. Epub 2009 Feb 13. |
83(1,1,1,3) | Details |
| 15475185 | Manakova S, Puttonen KA, Raasmaja A, Mannisto PT: The roles of dopamine transporter and Bcl-2 protein in the protection of CV1-P cells from 6-OHDA-induced toxicity. Toxicol Lett. 2004 Dec 1;154(1-2):117-23. The apparent entry of 6-OHDA into fibroblasts was decreased by the DAT inhibitor, 1-(2-bis-(4-fluorophenyl) methoxy) ethyl)-4-(3-phenyl-propyl) piperazine (GBR 12909). |
2(0,0,0,2) | Details |