| 11677139 |
Levin JI, Chen JM, Du MT, Nelson FC, Wehr T, DiJoseph JF, Killar LM, Skala S, Sung A, Sharr MA, Roth CE, Jin G, Cowling R, Di L, Sherman M, Xu ZB, March CJ, Mohler KM, Black RA, Skotnicki JS: The discovery of anthranilic acid-based MMP inhibitors. Bioorg Med Chem Lett. 2001 Nov 19;11(22):2975-8.
Piperazine 4u has been identified as a potent, selective, orally active inhibitor of MMP-9 and MMP-13. |
82(1,1,1,2) |
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| 20213245 |
Finlay TM, Jayanth P, Amith SR, Gilmour A, Guzzo C, Gee K, Beyaert R, Szewczuk MR: Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9. Glycoconj J. 2010 Apr;27(3):329-48. Epub 2010 Mar 6.
Pertussis toxin (PTX), a specific inhibitor of Galphai proteins of G-protein coupled receptor (GPCR) and the broad range inhibitors of matrix metalloproteinase (MMP) galardin and piperazine applied to live BMC-2, THP-1 and primary BM macrophage cells completely block TQ-induced sialidase activity. |
2(0,0,0,2) |
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