| Name | metalloproteinase |
|---|---|
| Synonyms | Leukolysin; MMP20; Matrix metalloproteinase 20; MMP25; MMP 25; MMP20A; MMPL 1; MMPL1… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11689071 | Ambrose Amin E, Welsh WJ: Three-dimensional quantitative structure-activity relationship (3D-QSAR) models for a novel class of piperazine-based stromelysin-1 (MMP-3) inhibitors: applying a "divide and conquer" strategy. J Med Chem. 2001 Nov 8;44(23):3849-55. Three-dimensional quantitative structure-activity relationship (3D-QSAR) models have been obtained using comparative molecular field analysis (CoMFA) for a novel series of piperazine-based matrix metalloproteinase inhibitors (MMPIs). |
31(0,1,1,1) | Details |
| 18396900 | Faust A, Waschkau B, Waldeck J, Holtke C, Breyholz HJ, Wagner S, Kopka K, Heindel W, Schafers M, Bremer C: Synthesis and evaluation of a novel fluorescent photoprobe for imaging matrix metalloproteinases. Bioconjug Chem. 2008 May;19(5):1001-8. Epub 2008 Apr 9. The measurement of matrix metalloproteinase (MMP) activity in diseases like inflammation, oncogenesis, or atherosclerosis in vivo is highly desirable. To minimize the interactions between activated MMPs and the dye of the conjugate 6, a PEGylated piperazine derivative was used as a spacer and an azide as a protected amino function. |
1(0,0,0,1) | Details |
| 12704411 | Johnson KJ, Peng KW, Allen C, Russell SJ, Galanis E: Targeting the cytotoxicity of fusogenic membrane glycoproteins in gliomas through protease-substrate interaction. Gene Ther. 2003 May;10(9):725-32. Use of the broad-spectrum MMP inhibitors, 1,10-phenanthroline and N--piperazine-carboxamide completely abolished the ability of MMP constructs to induce fusion. Here we report on the use of matrix metalloproteinase (MMP) cleavable linkers to target cytotoxicity of FMGs against gliomas. |
1(0,0,0,1) | Details |
| 20213245 | Finlay TM, Jayanth P, Amith SR, Gilmour A, Guzzo C, Gee K, Beyaert R, Szewczuk MR: Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9. Glycoconj J. 2010 Apr;27(3):329-48. Epub 2010 Mar 6. Pertussis toxin (PTX), a specific inhibitor of Galphai proteins of G-protein coupled receptor (GPCR) and the broad range inhibitors of matrix metalloproteinase (MMP) galardin and piperazine applied to live BMC-2, THP-1 and primary BM macrophage cells completely block TQ-induced sialidase activity. |
31(0,1,1,1) | Details |