| Name | sodium channel (protein family or complex) |
|---|---|
| Synonyms | Sodium channel |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18342401 | Catalano A, Carocci A, Corbo F, Franchini C, Muraglia M, Scilimati A, De Bellis M, De Luca A, Camerino DC, Sinicropi MS, Tortorella V: Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents. Eur J Med Chem. 2008 Nov;43(11):2535-40. Epub 2008 Jan 31. 1-Benzyl-N-(2,6-dimethylphenyl) piperidine-3-carboxamide and 4-benzyl-N-(2,6-dimethylphenyl) piperazine-2-carboxamide, two conformationally restricted analogues of tocainide, were designed and synthesized as voltage-gated skeletal muscle sodium channel blockers. |
32(0,1,1,2) | Details |
| 18501613 | Drizin I, Gregg RJ, Scanio MJ, Shi L, Gross MF, Atkinson RN, Thomas JB, Johnson MS, Carroll WA, Marron BE, Chapman ML, Liu D, Krambis MJ, Shieh CC, Zhang X, Hernandez G, Gauvin DM, Mikusa JP, Zhu CZ, Joshi S, Honore P, Marsh KC, Roeloffs R, Werness S, Krafte DS, Jarvis MF, Faltynek CR, Kort ME: Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain. Bioorg Med Chem. 2008 Jun 15;16(12):6379-86. Epub 2008 May 6. |
9(0,0,1,4) | Details |
| 16195688 | McCullough PA: Chronic angina: new medical options for treatment. Rev Cardiovasc Med. 2005 Summer;6(3):152-61. A new approach is represented by the piperazine derivatives trimetazidine (TMZ) and ranolazine (RNZ). RNZ has been separately classified as a late sodium channel inhibitor, which reverses action potential prolongation, suppresses early after-depolarizations, and terminates resultant ventricular tachycardia. |
1(0,0,0,1) | Details |