| Name | 5 HT 1F |
|---|---|
| Synonyms | 5 Hydroxytryptamine 1E like receptor; 5 Hydroxytryptamine receptor 1F; 5 HT 1F; 5 HT1F; 5 hydroxytryptamine (serotonin) receptor 1F; 5 hydroxytryptamine 1F receptor; HTR1EL; HTR1F… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11834243 | Bhalla P, Sharma HS, Wurch T, Pauwels PJ, Saxena PR: Molecular cloning and expression of the porcine trigeminal ganglion cDNA encoding a 5-ht (1F) receptor. Eur J Pharmacol. 2002 Feb 1;436(1-2):23-33. The affinities of several agonists (LY334370 (5-(4-fluorobenzoyl) amino-3-(1-methylpiperidin-4-yl)-1H- CP122638 (N-methyl-3 [pyrrolidin 2 (R)-yl methyl]-1H-indol-5-ylmethyl sulphonamide)=naratriptan =5HT> eletriptan> frovatriptan =avitriptan> dihydroergotamine> zolmitriptan> 5-carboxamidotryptamine> rizatri ptan> alniditan=donitriptan> L694247 (2-[5-[3-(4-methylsulphonylamino) benzyl-1,2,4-oxadiazol-5-yl]-1H-indole-3- yl] ethylamine) and putative antagonists (methiothepin> GR127935 (N-[4-methoxy-3-(4-methyl-1-piperazinyl) phenyl]-2'-methyl 4'-(5-methyl-1,2,4-oxadiazol-3-yl) [1,1-biphenyl]-4-carboxamide hydrochloride)> ritanserin> SB224289 (2,3,6,7-tetrahydro-1'-methyl-5-[2'-methyl-4'(5-methyl-1,2,4-oxadiazol-3-y l) biphenyl-4-carbonyl] furo [2,3-f] -3-spiro-4'-piperidine hydrochloride)> BRL155572 ([1-(3-chlorophenyl)-4-[3,3-diphenyl (2-(S,R) hydroxypropanyl) piperazine] hydrochloride)> ketanserin=pindolol) correlated highly with those described for the recombinant human 5-ht (1F) receptor (Spearman correlation coefficient; r (s)=0.942). |
38(0,1,1,8) | Details |
| 15178373 | Janssen P, Tack J, Sifrim D, Meulemans AL, Lefebvre RA: Influence of 5-HT1 receptor agonists on feline stomach relaxation. Eur J Pharmacol. 2004 May 25;492(2-3):259-67. Pre-treatment with -synthase inhibitors and different (1) receptor antagonists N-[2-[4-(2-methoxyphenyl)-1-piperazinyl] ethyl]-N-2-pyridinyl-cyclohexaneca rboxamide (WAY-100635), 2-methyl-4-(5-methyl-[1,2,4] oxadiazol-3-yl)-biphenyl-4-carboxylic-acid [4-m ethoxy-3-(4-methyl-piperazin-1-yl)-phenyl] amide (GR-127935), N-acetyl-5-hydroxytryptophyl--amide (5-HTP-DP) and 1-(2-methoxyphenyl)-4-[4-(2-phthalimido) butyl] piperazine-HCl (NAN-190) did not affect the -induced effect. Our results suggest that stimulation of 5-HT (1F) receptors induces feline stomach relaxation. |
1(0,0,0,1) | Details |