Protein Information

Name complex I
Synonyms 39kD; CI 39kD; Complex I; Complex I 39kD; NADH dehydrogenase (ubiquinone) Fe S protein 2 like; NADH ubiquinone oxidoreductase 39 kDa subunit mitochondrial; NADH ubiquinone oxidoreductase 39 kDa subunit; NDUFA 9…

Compound Information

Name piperazine
CAS piperazine

Reference List

PubMed Abstract RScore(About this table)
11078596 Stellwagen NC, Bossi A, Gelfi C, Righetti PG: DNA and buffers: are there any noninteracting, neutral pH buffers? . Anal Biochem. 2000 Dec 1;287(1):167-75.

Hence, the mixed DNA-borate complex is stabilized by the binding of additional borate ions, possibly forming bridges between the different DNAs.
Other neutral pH, amine-based buffers, such as Mops (3-[N-morpholino] propanesulfonic acid), Hepes (N-[2-hydroxyethyl] piperazine-N'-[2-ethanesulfonic acid]), Bes (N,N-bis [2-hydroxyethyl]-2-aminoethanesulfonic acid), Tes (N-tris [hydroxymethyl] methyl-2-aminoethanesulfonic acid), and tricine (N-tris [hydroxymethyl] methylglycine) also form complexes with DNA, giving distorted peaks in the electropherograms.
2(0,0,0,2) Details
20192227 Chattopadhyay T, Mukherjee M, Mondal A, Maiti P, Banerjee A, Banu KS, Bhattacharya S, Roy B, Chattopadhyay DJ, Mondal TK, Nethaji M, Zangrando E, Das D: A unique nickel system having versatile catalytic activity of biological significance. Inorg Chem. 2010 Apr 5;49(7):3121-9.

The X-ray single crystal structure analysis shows that the piperazine moieties assume the expected chair conformation and are protonated.
In acetonitrile medium, the complex is inactive to exhibit catecholase activity.
1(0,0,0,1) Details
11360653 Zhao X, Wei Y, Peng Z: [Phorbol-12-myristate-13-acetate and interferon-gamma synergistic induction of B7-1 expression in ovary carcinoma cells and immunological value]. Zhonghua Fu Chan Ke Za Zhi. 1999 Jul;34(7):414-6.

METHODS: Expression of costimulatory signals (B7-1), major histocompatibility complex (MHC-I, MHC-II) was analysed with flow cytometry.
The synergistic effect of PMA combined with IFN-gamma in the induction of B7-1 expression can be anatagonised by H7 [1-(5-isoquinolinesulfonyl)-2-methyl-Piperazine dihydrochloride].
1(0,0,0,1) Details
12737939 Liu X, Sahud MA: Glycoprotein IIb/IIIa complex is the target in mirtazapine-induced immune thrombocytopenia. Blood Cells Mol Dis. 2003 May-Jun;30(3):241-5.

Mirtazapine (MW 265.36), a tetracyclic antidepressant of the piperazine-azapine group which augments central noradrenergic and serotonergic activity, is currently used as an oral antidepressant.
1(0,0,0,1) Details
11989622 Bronowska A, Chilmonczyk Z, Les A, Edvardsen O, Ostensen R, Sylte I: Molecular dynamics of 5-HT1A and 5-HT2A serotonin receptors with methylated buspirone analogues. J Comput Aided Mol Des. 2001 Nov;15(11):1005-23.

It was found that due to the presence of the methyl group in the piperazine ring the ligand position alters and the structure of the ligand-receptor complex is modified.
81(1,1,1,1) Details
18781777 Ichimaru N, Murai M, Kakutani N, Kako J, Ishihara A, Nakagawa Y, Nishioka T, Yagi T, Miyoshi H: Synthesis and characterization of new piperazine-type inhibitors for mitochondrial NADH-ubiquinone oxidoreductase (complex I). Biochemistry. 2008 Oct 7;47(40):10816-26. Epub 2008 Sep 10.
5(0,0,0,5) Details