| Name | histamine H3 receptors |
|---|---|
| Synonyms | G protein coupled receptor 97; GPCR97; HH3R; HRH 3; HRH3; Histamine H3 receptor; Histamine receptor H3; Histamine H3 receptors… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12755406 | Faghih R, Phelan K, Esbenshade TA, Miller TR, Kang CH, Krueger KM, Yao BB, Fox GB, Bennani YL, Hancock AA: D- piperazine-amides: novel non- antagonists of the histamine H3 receptor. Inflamm Res. 2003 Apr;52 Suppl 1:S47-8. |
81(1,1,1,1) | Details |
| 15642406 | Walczynski K, Zuiderveld OP, Timmerman H: Non- H3 ligands. Eur J Med Chem. 2005 Jan;40(1):15-23. In search for a new lead of non- histamine H3-receptor antagonists, a series of 1 [(2-thiazolopyridine)-4-n-propyl] piperazines, the analogous 1-[(2-oxazolopyridine)-4-npropyl] piperazines, 1-[(2-benzothiazole)-4-n-propyl] piperazine and 1-[(2-benzooxazole) 4-n-propyl] piperazine were prepared and in vitro tested as H3-receptor antagonists (the electrically evoked contraction of the guinea-pig jejunum). |
31(0,1,1,1) | Details |
| 12606603 | Esbenshade TA, Krueger KM, Miller TR, Kang CH, Denny LI, Witte DG, Yao BB, Fox GB, Faghih R, Bennani YL, Williams M, Hancock AA: Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. J Pharmacol Exp Ther. 2003 Jun;305(3):887-96. Epub 2003 Feb 20. Here we present the in vitro pharmacological data for two novel piperazine amide ligands, A-304121 [4-(3-((2R)-2-aminopropanoyl-1-piperazinyl) propoxy) phenyl) cyclopropylmetha none] and A-317920 [N-((1R)-2-(4-(3-(4-(cyclopropylcarbonyl) phenoxy) propyl)-1-piperazinyl)-1- methyl-2-oxo-ethyl-)-2-furamide], and compare them with the H3R antagonists ciproxifan, clobenpropit, and thioperamide. |
2(0,0,0,2) | Details |
| 12606600 | Fox GB, Pan JB, Radek RJ, Lewis AM, Bitner RS, Esbenshade TA, Faghih R, Bennani YL, Williams M, Yao BB, Decker MW, Hancock AA: Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. J Pharmacol Exp Ther. 2003 Jun;305(3):897-908. Epub 2003 Feb 20. A-304121 and A-317920 represent a series of novel, H3R-selective piperazine amides that enhance cognition in vivo, which could offer advantages over existing H3R antagonists or cognition-enhancing agents. Pharmacological blockade of central histamine H3 receptors (H3Rs) enhances cognition in rodents and offers promise for the clinical treatment of neurological disorders. |
1(0,0,0,1) | Details |