| Name | Aurora A |
|---|---|
| Synonyms | serine/threonine kinase 6; AIK; ARK 1; ARK1; AURA; AURKA; AURORA 2; AURORA2… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16891462 | Warner SL, Bashyam S, Vankayalapati H, Bearss DJ, Han H, Mahadevan D, Von Hoff DD, Hurley LH: Identification of a lead small-molecule inhibitor of the Aurora kinases using a structure-assisted, fragment-based approach. Mol Cancer Ther. 2006 Jul;5(7):1764-73. Based on these computational methods, a new generation of inhibitors derived from quinazoline and pyrimidine-based tricyclic scaffolds were synthesized and evaluated for Aurora A kinase inhibitory activity, which led to the identification of 4-(6,7-dimethoxy-9H-1,3,9-triaza-fluoren-4-yl)-piperazine-1-carbothioic acid [4-(pyrimidin-2-ylsulfamoyl)-phenyl]-amide. |
33(0,1,1,3) | Details |
| 16152590 | Weiderhold KN, Randall-Hlubek DA, Polin LA, Hamel E, Mooberry SL: CB694, a novel antimitotic with antitumor activities. Int J Cancer. 2006 Feb 15;118(4):1032-40. CB694 caused phosphorylation of Aurora A within 8 hr of treatment, and increases in Aurora A protein levels were coincident with mitotic accumulation. During the course of a mechanism-based screening program aimed at identifying new antimitotic agents, a novel microtubule depolymerizing piperazine derivative, 1-(5-chloro-2-methoxybenzoyl)-4-(3-chlorophenyl) piperazine, was identified. |
1(0,0,0,1) | Details |