Protein Information

Name JNK3
Synonyms C JUN kinase 3; JNK 3; JNK3; JNK3 alpha protein kinase; JNK3A; MAP kinase; MAP kinase 10; MAP kinase p49 3F12…

Compound Information

Name piperazine
CAS piperazine

Reference List

PubMed Abstract RScore(About this table)
20071169 Tan X, Tester RW, Luedtke GR, Chakravarty S, Mavunkel BJ, Perumattam JJ, Lu Q, Nashashibi I, Jung J, Hu J, Liclican A, Almirez R, Tabora J, Tran V, Laney M, Levy DE, Dugar S: Design and synthesis of piperazine-indole p38alpha MAP kinase inhibitors with improved pharmacokinetic profiles. Bioorg Med Chem Lett. 2010 Feb 1;20(3):828-31. Epub 2010 Jan 4.
32(0,1,1,2) Details
19433357 Shin Y, Chen W, Habel J, Duckett D, Ling YY, Koenig M, He Y, Vojkovsky T, LoGrasso P, Kamenecka TM: Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3344-7. Epub 2009 Mar 26.

The X-ray crystal structure of 4g showed a unique binding mode different from other well known JNK3 inhibitors.
1(0,0,0,1) Details