| Name | Connexin 43 |
|---|---|
| Synonyms | CX43; Connexin 43; Cx43; DFNB38; GJA 1; GJA1; GJAL; Gap junction 43 kDa heart protein… |
| Name | lindane |
|---|---|
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15749814 | Ke FC, Fang SH, Lee MT, Sheu SY, Lai SY, Chen YJ, Huang FL, Wang PS, Stocco DM, Hwang JJ: Lindane, a gap junction blocker, suppresses FSH and transforming growth factor beta1-induced connexin43 gap junction formation and steroidogenesis in rat granulosa cells. J Endocrinol. 2005 Mar;184(3):555-66. Immunoblotting analysis showed that FSH plus TGF beta1 dramatically increased the levels of phosphorylated Cx43 without significantly influencing the level of nonphosphorylated Cx43, and this stimulatory effect was completely suppressed by lindane. |
177(1,4,4,7) | Details |
| 18040759 | Sidorova TS, Matesic DF: Protective effect of the natural product, chaetoglobosin K, on lindane- and dieldrin-induced changes in astroglia: identification of activated signaling pathways. Pharm Res. 2008 Jun;25(6):1297-308. CONCLUSION: ChK's protective effects, both preventative and reversal, on lindane and dieldrin inhibition of gap junction-mediated communication are associated with stabilization and reappearance of the connexin 43 P2 phosphoform and may be mediated by the Akt pathway. |
113(1,2,2,3) | Details |
| 11532877 | Defamie N, Mograbi B, Roger C, Cronier L, Malassine A, Brucker-Davis F, Fenichel P, Segretain D, Pointis G: Disruption of gap junctional intercellular communication by lindane is associated with aberrant localization of connexin43 and zonula occludens-1 in 42GPA9 Sertoli cells. Carcinogenesis. 2001 Sep;22(9):1537-42. These results suggest that lindane inhibits GJIC between Sertoli cells and that aberrant Cx43/ZO-1 localization may be responsible for this effect. |
82(1,1,1,2) | Details |
| 19033388 | Gilleron J, Fiorini C, Carette D, Avondet C, Falk MM, Segretain D, Pointis G: Molecular reorganization of Cx43, Zo-1 and Src complexes during the endocytosis of gap junction plaques in response to a non-genomic carcinogen. J Cell Sci. 2008 Dec 15;121(Pt 24):4069-78. Epub 2008 Nov 25. |
7(0,0,0,7) | Details |
| 19321666 | Das S, Smith TD, Sarma JD, Ritzenthaler JD, Maza J, Kaplan BE, Cunningham LA, Suaud L, Hubbard MJ, Rubenstein RC, Koval M: ERp29 restricts Connexin43 oligomerization in the endoplasmic reticulum. . Mol Biol Cell. 2009 May;20(10):2593-604. Epub 2009 Mar 25. Connexin43 (Cx43) is a gap junction protein that forms multimeric channels that enable intercellular communication through the direct transfer of signals and metabolites. |
7(0,0,0,7) | Details |
| 8824497 | Guan X, Ruch RJ: Gap junction endocytosis and lysosomal degradation of connexin43-P2 in WB-F344 rat liver epithelial cells treated with DDT and lindane. Carcinogenesis. 1996 Sep;17(9):1791-8. Treatment of WB-F344 rat liver epithelial cells with DDT (1,1-bis (p-chlorophenyl)-2,2,2-trichloroethane) or lindane induces a loss of gap junction plaques and a decrease in the phosphorylated gap junction protein connexin43-P2 (Cx43-P2), which is associated with the plaques. |
248(3,3,3,8) | Details |
| 12807735 | Mograbi B, Corcelle E, Defamie N, Samson M, Nebout M, Segretain D, Fenichel P, Pointis G: Aberrant Connexin 43 endocytosis by the carcinogen lindane involves activation of the ERK/mitogen-activated protein kinase pathway. Carcinogenesis. 2003 Aug;24(8):1415-23. Epub 2003 Jun 5. Inhibition of ERK pathway by PD98059, a MEK1-specific inhibitor, prevented Lindane-induced Cx43 phosphorylation, restored Cx43 membranous localization and gap junction coupling. |
231(2,4,5,6) | Details |
| 15194225 | Segretain D, Fiorini C, Decrouy X, Defamie N, Prat JR, Pointis G: A proposed role for ZO-1 in targeting connexin 43 gap junctions to the endocytic pathway. Biochimie. 2004 Apr-May;86(4-5):241-4. |
6(0,0,0,6) | Details |
| 17620312 | Jin EJ, Lee SY, Jung JC, Bang OS, Kang SS: TGF-beta3 inhibits chondrogenesis of cultured chick leg bud mesenchymal cells via downregulation of connexin 43 and integrin beta4. J Cell Physiol. 2008 Feb;214(2):345-53. Treatment of these cells with lindane, a general gap junction blocker, or expression of dominant negative Cx43 increased apoptotic cell death and decreased the level of integrin beta4 protein, in a manner similar to that observed when these cells were exposed to TGF-beta3. |
3(0,0,0,3) | Details |
| 10518488 | Levin M, Mercola M: Gap junction-mediated transfer of left-right patterning signals in the early chick blastoderm is upstream of Shh asymmetry in the node. Development. 1999 Nov;126(21):4703-14. Treatment of cultured chick embryos with lindane, which diminishes gap junctional communication, frequently unbiased normal LR asymmetry of Shh and Nodal gene expression, causing the normally left-sided program to be recapitulated symmetrically on the right side of the embryo. A survey of early expression of connexin mRNAs revealed that Cx43 is present throughout the blastoderm at Hamburger-Hamilton stage 2-3, prior to known asymmetric gene expression. |
2(0,0,0,2) | Details |
| 12919956 | Hamada N, Kodama S, Suzuki K, Watanabe M: Gap junctional intercellular communication and cellular response to heat stress. Carcinogenesis. 2003 Nov;24(11):1723-8. Epub 2003 Aug 14. Persistent heat treatment augmented Cx43 phosphorylation in a heat- and time-dependent fashion and this phosphorylation was recovered after heat shock. First, we investigated whether the abolition of GJIC by lindane affects heat sensitivity in normal human cells. |
2(0,0,0,2) | Details |
| 16267011 | Persaud R, Zhou H, Baker SE, Hei TK, Hall EJ: Assessment of low linear energy transfer radiation-induced bystander mutagenesis in a three-dimensional culture model. Cancer Res. 2005 Nov 1;65(21):9876-82. The free radical scavenger DMSO or the gap junction inhibitor Lindane within the clusters significantly reduced the mutation incidence. |
0(0,0,0,0) | Details |