| 15740781 |
Shimazaki T, Chaki S: Anxiolytic-like effect of a selective and non-peptidergic melanocortin 4 receptor antagonist, MCL0129, in a social interaction test. Pharmacol Biochem Behav. 2005 Mar;80(3):395-400. Epub 2005 Jan 16.
We investigated the involvement of MC4 receptor in a social interaction test, using Ac-[Nle (4),Asp (5),D-Phe (7),Lys (10)] alpha-MSH-(4-10)-NH2 (MT II), an MC4 receptor agonist, and 1-[(S)-2-(4-fluorophenyl)-2-(4-isopropylpiperadin-1-yl) ethyl]-4-[4-(2-meth oxynaphthalen-1-yl) butyl] piperazine (MCL0129), a selective and nonpeptide MC4 receptor antagonist. |
31(0,1,1,1) |
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| 16337261 |
Chaki S, Oshida Y, Ogawa S, Funakoshi T, Shimazaki T, Okubo T, Nakazato A, Okuyama S: MCL0042: a nonpeptidic MC4 receptor antagonist and serotonin reuptake inhibitor with anxiolytic- and antidepressant-like activity. Pharmacol Biochem Behav. 2005 Dec;82(4):621-6. Epub 2005 Dec 6.
MCL0042 attenuated [Nle (4),d-Phe (7)] alpha-MSH-increased cAMP formation in MC4 receptor expressing cells, and it inhibited [(3) H] serotonin uptake by rat brain synaptosomes; thus, MCL0042 is an MC4 receptor antagonist and serotonin transporter inhibitor. |
1(0,0,0,1) |
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