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Zhu J, Mactutus CF, Wallace DR, Booze RM: HIV-1 Tat protein-induced rapid and reversible decrease in [3H] dopamine uptake: dissociation of [3H] dopamine uptake and [3H] 2beta-carbomethoxy-3-beta-(4-fluorophenyl) tropane (WIN 35,428) binding in rat striatal synaptosomes. J Pharmacol Exp Ther. 2009 Jun;329(3):1071-83. Epub 2009 Mar 26.
Rat striatal synaptosomes were incubated with recombinant Tat (1-86) protein, and [(3) H] DA uptake and the binding of [(3) H] 2beta-carbomethoxy-3-beta-(4-fluorophenyl) tropane (WIN 35,428) and [(3) H] 1-[2-(diphenylmethoxy) ethyl]-4-(3-phenylpropyl)-piperazine (GBR 12935) were determined. |
33(0,1,1,3) |
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