| Name | liver carboxylesterase |
|---|---|
| Synonyms | ACAT; Cholesteryl ester hydrolase; CES1; SES 1; SES1; ANAE; Acid esterase; Acyl coenzyme A cholesterol acyltransferase… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12736497 | Ohishi K, Sawada H, Yoshida Y, Hatano H, Aiyama R, Watanabe T, Yokokura T: The metabolic stability of acyl- O-acyltransferase (ACAT) inhibitors, N-(4-benzyloxy-3, 5-dimethoxycinnamoyl)-N'-(2, 4-dimethylphenyl) piperazine (YIC-708-424) and its derivatives in rat liver and intestinal epithelium. Biol Pharm Bull. 2003 May;26(5):600-7. |
63(0,2,2,3) | Details |
| 12913263 | Ohishi K, Sawada H, Yoshida Y, Yokoi W, Hatano H, Aiyama R, Watanabe T, Yokokura T: Inhibitory effects of N-(3,5-dimethoxy-4-n-octyloxycinnamoyl)-N'-(3,4-dimethylphenyl) piperazine (YIC-C8-434), an acyl-CoA:cholesterol O-acyltransferase inhibitor, on esterification in the intestine and liver. Biol Pharm Bull. 2003 Aug;26(8):1125-8. The effects of an acyl-CoA:cholesterol O-acyltransferase (ACAT) inhibitor, N-(3,5-dimethoxy-4-n-octyloxycinnamoyl)-N'-(3,4-dimethylphenyl) piperazine (YIC-C8-434), on esterification in the intestine and liver were investigated in vitro and in vivo. |
32(0,1,1,2) | Details |
| 11456087 | Ohishi K, Aiyama R, Hatano H, Yoshida Y, Wada Y, Yokoi W, Sawada H, Watanabe T, Yokokura T: Structure-activity relationships of N-(3,5-dimethoxy-4-n-octyloxycinnamoyl)-N'-(3,4-dimethylphenyl) piperazine and analogues as inhibitors of acyl- O-acyltransferase. Chem Pharm Bull. 2001 Jul;49(7):830-9. A novel series of acyl- O-acyltransferase (ACAT) inhibitors were synthesized from a lead compound, 1-(4--3-methoxyphenyl)-7-phenylhept-1-en-3-one (1, Yakuchinone B) through a modification of three regions (A, B, C) in the molecule. |
4(0,0,0,4) | Details |
| 18448139 | Bate C, Tayebi M, Williams A: esterification reduces the neurotoxicity of prions. Neuropharmacology. 2008 Jun;54(8):1247-53. Epub 2008 Apr 9. Here we report that three acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitors, TMP-153, FR179254 or YIC-C8-434, were more toxic to prion-infected neuronal cell lines (ScGT1 and ScN2a cells) than to their uninfected equivalents (GT1 and N2a cells). |
2(0,0,0,2) | Details |
| 15299073 | Yoon KJ, Hyatt JL, Morton CL, Lee RE, Potter PM, Danks MK: Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application. Mol Cancer Ther. 2004 Aug;3(8):903-9. A secondary goal was to develop molecules that specifically inhibit activation of CPT-11 by a rabbit liver carboxylesterase (rCE). rCE is the most efficient CPT-11-activating enzyme thus far identified, and this enzyme is being developed for viral-directed enzyme prodrug therapy applications. Lead compounds are derivatives of nitrophenol having 4-(furan-2-carbonyl)-piperazine-1-carboxylic acid or 4-[(4-chlorophenyl)-phenylmethyl]-piperazine-1-carboxylic acid substitutions in the p position. |
1(0,0,0,1) | Details |
| 11719709 | Kaneko K, Uchida K, Kobayashi T, Miura K, Tanokura K, Hoshino K, Kato I, Onoue M, Yokokura T: Sex-dependent toxicity of a novel acyl-CoA:cholesterol acyltransferase inhibitor, YIC-C8-434, in relation to sex-specific forms of cytochrome P450 in rats. Toxicol Sci. 2001 Dec;64(2):259-68. YIC-C8-434 is a novel inhibitor of acyl coenzyme A:cholesterol acyltransferase (ACAT). |
1(0,0,0,1) | Details |