| Name | MT 2 |
|---|---|
| Synonyms | CES 1; CES1; MT 2A; MT II; MT IIa; MT 2; MT2; MT2A… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15740781 | Shimazaki T, Chaki S: Anxiolytic-like effect of a selective and non-peptidergic melanocortin 4 receptor antagonist, MCL0129, in a social interaction test. Pharmacol Biochem Behav. 2005 Mar;80(3):395-400. Epub 2005 Jan 16. We investigated the involvement of MC4 receptor in a social interaction test, using Ac-[Nle (4),Asp (5),D- (7),Lys (10)] alpha-MSH-(4-10)-NH2 (MT II), an MC4 receptor agonist, and 1-[(S)-2-(4-fluorophenyl)-2-(4-isopropylpiperadin-1-yl) ethyl]-4-[4-(2-meth oxynaphthalen-1-yl) butyl] piperazine (MCL0129), a selective and nonpeptide MC4 receptor antagonist. |
32(0,1,1,2) | Details |
| 18582863 | Kimura Y, Naitou Y, Wanibuchi F, Yamaguchi T: 5-HT (2C) receptor activation is a common mechanism on proerectile effects of apomorphine, and melanotan-II in rats. Eur J Pharmacol. 2008 Jul 28;589(1-3):157-62. Epub 2008 May 24. In this study, in order to clarify these matters, we examined the effects of a selective 5-HT (2B)/5-HT (2C) receptors antagonist, 1-(1-methylindol-5-yl)-3-(3-pyridyl) urea (SB200646) and a selective 5-HT (2C) receptor antagonist, 6-chloro-5-methyl-1-[6-(2-methylpyridin-3-yloxy) pyridin-3-yl carbamoyl] indoline (SB242084) on penile erections induced by a receptor agonist, 10, 11-dihydroxyaporphine (apomorphine), or a melanocortin receptor agonist, melanotan-II (MT-II) in rats. |
2(0,0,0,2) | Details |
| 12704411 | Johnson KJ, Peng KW, Allen C, Russell SJ, Galanis E: Targeting the cytotoxicity of fusogenic membrane glycoproteins in gliomas through protease-substrate interaction. Gene Ther. 2003 May;10(9):725-32. Use of the broad-spectrum MMP inhibitors, 1,10-phenanthroline and N--piperazine-carboxamide completely abolished the ability of MMP constructs to induce fusion. Establishment of stable tranfectants expressing the membrane-type MMPs, MT-1 MMP and MT-2 MMP did restore fusion in the MMP-poor cell line TE671 after transfection with GALV M40, thus indicating that both membrane-type MMPs and soluble MMPs activate the MMP cleavable constructs. |
1(0,0,0,1) | Details |
| 12643943 | Mattson RJ, Catt JD, Keavy D, Sloan CP, Epperson J, Gao Q, Hodges DB, Iben L, Mahle CD, Ryan E, Yocca FD: Indanyl piperazines as melatonergic MT2 selective agents. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1199-202. Optimization of a benzyl piperazine pharmacophore produced N-acyl-4-indanyl-piperazines that bind with high affinity to melatonergic MT (2) receptors. (R)-4-(2,3-dihydro-6-methoxy-1H-inden-1-yl)-N-ethyl-1-piperazine-carboxami de (13) is a water soluble, selective MT (2) agonist, which produces advances in circadian phase in rats at doses of 1-56 mg/kg that are no different from those of at 1 mg/kg. |
0(0,0,0,0) | Details |