Protein Information

Name Rhodanese
Synonyms RDS; Rhodanese; TST; TST protein; Thiosulfate sulfurtransferase; Thiosulfate sulfurtransferase variant; thiosulfate sulfurtransferase (rhodanese); Rhodaneses…

Compound Information

Name hydrogen cyanide
CAS hydrocyanic acid

Reference List

PubMed Abstract RScore(About this table)
2006499 Lewis JL, Rhoades CE, Gervasi PG, Griffith WC, Dahl AR: The cyanide-metabolizing enzyme rhodanese in human nasal respiratory mucosa. Toxicol Appl Pharmacol. 1991 Mar 15;108(1):114-20.

The high rhodanese activity in rat nasal epithelium may provide a mechanism for detoxicating inhaled hydrogen cyanide and may also play a role in olfaction by limiting the concentrations of cyanide in the nasal epithelium.
87(1,1,1,7) Details
2919401 Dahl AR: The cyanide-metabolizing enzyme rhodanese in rat nasal respiratory and olfactory mucosa. Toxicol Lett. 1989 Feb;45(2-3):199-205.

Hydrogen cyanide is a commonly occurring and highly toxic air pollutant.
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19625201 Zottola MA: A partial exploration of the potential energy surfaces of SCN and HSCN: implications for the enzyme-mediated detoxification of cyanide. J Mol Graph Model. 2009 Sep;28(2):183-6. Epub 2009 Jul 4.

The body uses the sulfur transferase enzyme rhodanese to detoxify cyanide via conversion of cyanide to thiocyanate.
This paper explores the potential energy surfaces for the conversion of cyanide anion and hydrogen cyanide to thiocyanate anion and thiocyanic acid, respectively.
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18199034 Broderick KE, Chan A, Balasubramanian M, Feala J, Reed SL, Panda M, Sharma VS, Pilz RB, Bigby TD, Boss GR: Cyanide produced by human isolates of Pseudomonas aeruginosa contributes to lethality in Drosophila melanogaster. J Infect Dis. 2008 Feb 1;197(3):457-64.

P. aeruginosa PAO1 strain with a mutation in the hydrogen cyanide synthase gene cluster was much less toxic to flies than the parental cyanogenic strain or 2 knock-in strains.
Transgenic flies overexpressing rhodanese, which detoxifies cyanide by converting it to thiocyanate, were resistant to cyanide and the increased virulence of cyanogenic strains.
1(0,0,0,1) Details
16661359 Miller JM, Conn EE: Metabolism of Hydrogen Cyanide by Higher Plants. Plant Physiol. 1980 Jun;65(6):1199-1202.

The enzymes investigated were beta-cyanoalanine synthase, rhodanese and formamide hydrolyase. beta-Cyanoalanine synthase was found to be present in every higher plant tested whereas rhodanese was found to occur far less commonly in plants.
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