Protein Information

Name methemoglobin
Synonyms Abnormal hemoglobin; G gamma globin; Gamma 2 globin; HBG 2; HBG2; Hb F Ggamma; Hemoglobin gamma G; Hemoglobin gamma 2 chain…

Compound Information

Name hydrogen cyanide
CAS hydrocyanic acid

Reference List

PubMed Abstract RScore(About this table)
9348377 Wu JS, Luttmann DR, Meininger TA, Soper NJ: Production and systemic absorption of toxic byproducts of tissue combustion during laparoscopic surgery. Surg Endosc. 1997 Nov;11(11):1075-9.

In a porcine model of laparoscopic surgery with smoke production, our aims were to assess (1) the relationship between levels of intraperitoneal carbon monoxide (CO) and systemic carboxyhemoglobin (COHb) and methemoglobin (MetHb), and (2) intraperitoneal concentrations of other noxious gases, including hydrogen cyanide (HCN), acrylonitrile (Acr), and benzene (Bzn).
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200533 Weger N: [Antidotes in acute poisonings] . Fortschr Med. 1977 Oct 27;95(40):2409-12.


In methemoglobin-poisoning the reduction of ferrihemoglobin is accelerated when toluidine-blue is applied intravenously.
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2648673 Hoffman RS, Sauter D: Methemoglobinemia resulting from smoke inhalation. Vet Hum Toxicol. 1989 Apr;31(2):168-70.

More recently, cyanide poisoning has been described from the inhalation of hydrogen cyanide liberated from of burning plastics (1).
Relatively low levels of methemoglobin could complicate concomitant carbon monoxide poisoning by additive or synergistic effects on oxygen binding and delivery.
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17210205 Lee J, Mukai D, Kreuter K, Mahon S, Tromberg B, Brenner M: Potential interference by hydroxocobalamin on cooximetry hemoglobin measurements during cyanide and smoke inhalation treatments. Ann Emerg Med. 2007 Jun;49(6):802-5. Epub 2007 Jan 8.


Because of its intense light absorbance in visible wavelengths (absorption peak at 532 nm), we investigate potential interference effects of OHCob on total hemoglobin concentration (tHb), carboxyhemoglobin (COHb), methemoglobin (MetHb), and oxyhemoglobin (Hb-O2) cooximetry measurement values in blood.
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