Protein Information

Name TAK1
Synonyms NR2C2; TAK 1; TAK1; Nuclear hormone receptor TR4; Orphan nuclear receptor TAK1; Orphan nuclear receptor TR4; TR2R1; TR4…

Compound Information

Name niclosamide
CAS

Reference List

PubMed Abstract RScore(About this table)
20215516 Jin Y, Lu Z, Ding K, Li J, Du X, Chen C, Sun X, Wu Y, Zhou J, Pan J: Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species. Cancer Res. 2010 Mar 15;70(6):2516-27. Epub 2010 Mar 9.

Niclosamide inhibited the steps TAK1--> IkappaB kinase (IKK) and IKK--> IkappaBalpha.
81(1,1,1,1) Details