| Name | Dishevelled 2 |
|---|---|
| Synonyms | DSH homolog 2; DVL 2; DVL2; Dishevelled 2; Segment polarity protein dishevelled homolog DVL 2; dishevelled 2 (homologous to Drosophila dsh); Dishevelled 2s; Segment polarity protein dishevelled homolog DVL 2s… |
| Name | niclosamide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19772353 | Chen M, Wang J, Lu J, Bond MC, Ren XR, Lyerly HK, Barak LS, Chen W: The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. Biochemistry. 2009 Nov 3;48(43):10267-74. We now report that the anti-helminthic niclosamide, a drug used for the treatment of tapeworm, promotes Frizzled1 endocytosis, downregulates Dishevelled-2 protein, and inhibits Wnt3A-stimulated beta-catenin stabilization and LEF/TCF reporter activity. |
31(0,1,1,1) | Details |