| Name | cytochrome P450 2E1 |
|---|---|
| Synonyms | CPE 1; Flavoprotein linked monooxygenase; Xenobiotic monooxygenase; Microsomal monooxygenase; CPE1; CYP2E; CYP2E1; CYP2E1 protein… |
| Name | cresol |
|---|---|
| CAS | methylphenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9253143 | Kim H, Wang RS, Elovaara E, Raunio H, Pelkonen O, Aoyama T, Vainio H, Nakajima T: Cytochrome P450 isozymes responsible for the metabolism of toluene and styrene in human liver microsomes. Xenobiotica. 1997 Jul;27(7):657-65. Mean expression levels of immunochemically detected CYP1A2/1 and CYP2B6 were almost 3-fold higher in Finnish microsomes, whereas CYP2E1 was 1.7-fold higher in Chinese samples. 4. |
3(0,0,0,3) | Details |
| 9065730 | Nakajima T, Wang RS, Elovaara E, Gonzalez FJ, Gelboin HV, Raunio H, Pelkonen O, Vainio H, Aoyama T: Toluene metabolism by cDNA-expressed human hepatic cytochrome P450. . Biochem Pharmacol. 1997 Feb 7;53(3):271-7. Of the eleven human CYP forms studied, CYP2E1 was the most active in forming benzyl followed by CYP2B6, CYP2C8, CYP1A2, and CYP1A1, in that order. |
2(0,0,0,2) | Details |
| 8870991 | Gelboin HV, Goldfarb I, Krausz KW, Grogan J, Korzekwa KR, Gonzalez FJ, Shou M: Inhibitory and noninhibitory monoclonal antibodies to human cytochrome P450 2E1. Chem Res Toxicol. 1996 Sep;9(6):1023-30. Thus, h2E1 was responsible for the following percentages of the total metabolism in human liver: p-nitroanisole (35%), phenanthrene (23%), methylanisole to cresol (25%), methylanisole to methoxybenzyl (12%), toluene (40%), and chlorzoxazone (72%). |
2(0,0,0,2) | Details |
| 8579380 | Kawamoto T, Koga M, Oyama T, Kodama Y: Habitual and genetic factors that affect urinary background levels of biomarkers for organic solvent exposure. Arch Environ Contam Toxicol. 1996 Jan;30(1):114-20. The genotypes of five metabolizing enzymes, that is, low Km aldehyde dehydrogenase (ALDH2), polymorphic N-acetyl transferase (NAT2), cytochrome P-4501A1 (CYP1A1), cytochrome P-4502E1 (CYP2E1), and glutathione-S-transferase mu (GSTM1) were determined form peripheral blood samples. |
1(0,0,0,1) | Details |
| 1602390 | Nakajima T, Wang RS, Katakura Y, Kishi R, Elovaara E, Park SS, Gelboin HV, Vainio H: Sex-, age- and pregnancy-induced changes in the metabolism of toluene and trichloroethylene in rat liver in relation to the regulation of cytochrome P450IIE1 and P450IIC11 content. J Pharmacol Exp Ther. 1992 Jun;261(3):869-74. |
2(0,0,0,2) | Details |
| 1417939 | Sequeira DJ, Eyer CS, Cawley GF, Nick TG, Backes WL: Ethylbenzene-mediated induction of cytochrome P450 isozymes in male and female rats. Biochem Pharmacol. 1992 Sep 25;44(6):1171-82. Western immunoblotting indicated that ethylbenzene treatment induced cytochrome P450 2B1/2B2 to a greater extent in male rats and cytochrome P450 2E1 only in females. |
1(0,0,0,1) | Details |