Protein Information

Name thrombin
Synonyms Coagulation factor II; Coagulation factor II variant; F2; F2 protein; F2 protein precursor; Factor II; PT; Prothrombin…

Compound Information

Name cresol
CAS methylphenol

Reference List

PubMed Abstract RScore(About this table)
15664436 Chan CP, Yuan-Soon H, Wang YJ, Lan WH, Chen LI, Chen YJ, Lin BR, Chang MC, Jeng JH: Inhibition of cyclooxygenase activity, platelet aggregation and thromboxane B2 production by two environmental toxicants: m- and o-cresol. Toxicology. 2005 Mar 1;208(1):95-104.

Although m- and o-cresol (<1 mM) showed little effect on thrombin-induced platelet aggregation, they effectively inhibited the thrombin-induced platelet TXB (2) production.
Cresol is a well-known environmental pollutant, toluene metabolite, uremic toxicant and accidental poisoning product.
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2536271 Ciavatti M, Blache D, Renaud S: Hormonal contraceptive increases plasma lipid peroxides in female rats. Arteriosclerosis. 1989 Jan-Feb;9(1):84-9.


Thrombin-induced aggregation of control platelets was markedly enhanced after incubation for 4 (p less than 0.025) to 60 (p less than 0.001) minutes in OC as compared with control plasma.
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7864194 Blache D: Involvement of hydrogen and lipid peroxides in acute tobacco smoking-induced platelet hyperactivity. Am J Physiol. 1995 Feb;268(2 Pt 2):H679-85.


This peroxidized FFA fraction enhanced the thrombin-induced aggregation of platelets from nonsmokers.
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