Protein Information

Name alcohol dehydrogenase (protein family or complex)
Synonyms ADH; alcohol dehydrogenase; alcohol dehydrogenases

Compound Information

Name cresol
CAS methylphenol

Reference List

PubMed Abstract RScore(About this table)
743216 Keat MJ, Hopper DJ: The aromatic alcohol dehydrogenases in Pseudomonas putida N.C.I.B. 9869 grown on 3,5-xylenol and p-cresol. Biochem J. 1978 Nov 1;175(2):659-67.

3(0,0,0,3) Details
12057198 Chen ZW, Matsushita K, Yamashita T, Fujii TA, Toyama H, Adachi O, Bellamy HD, Mathews FS: Structure at 1.9 A resolution of a quinohemoprotein alcohol dehydrogenase from Pseudomonas putida HK5. Structure. 2002 Jun;10(6):837-49.

2(0,0,0,2) Details
18539747 Wohlbrand L, Wilkes H, Halder T, Rabus R: Anaerobic degradation of p-ethylphenol by "Aromatoleum aromaticum" strain EbN1: pathway, regulation, and involved proteins. J Bacteriol. 2008 Aug;190(16):5699-709. Epub 2008 Jun 6.


Among them are a p-cresol methylhydroxylase-like protein (PchCF), two predicted alcohol dehydrogenases (ChnA and EbA309), a biotin-dependent carboxylase (XccABC), and a thiolase (TioL).
1(0,0,0,1) Details
16085815 Garcia-Pena I, Hernandez S, Auria R, Revah S: Correlation of biological activity and reactor performance in biofiltration of toluene with the fungus Paecilomyces variotii CBS115145. Appl Environ Microbiol. 2005 Aug;71(8):4280-5.


In liquid cultures with toluene as a substrate, the activity of toluene oxygenase (TO) was 5.6 nmol of O2/min/mg of biomass, and that of benzyl alcohol dehydrogenase was 16.2 nmol of NADH/min/mg of protein.
1(0,0,0,1) Details
1781729 Altenschmidt U, Fuchs G: Anaerobic degradation of toluene in denitrifying Pseudomonas sp.: indication for toluene methylhydroxylation and benzoyl-CoA as central aromatic intermediate. Arch Microbiol. 1991;156(2):152-8.


In extracts of cells anaerobically grown on toluene, benzyl alcohol dehydrogenase, benzaldehyde dehydrogenase, and benzoyl-CoA synthetase (AMP forming) activities were present.
1(0,0,0,1) Details
836020 Sekiguchi J, Gaucher GM: Conidiogenesis and secondary metabolism in Penicillium urticae. Appl Environ Microbiol. 1977 Jan;33(1):147-58.


A mutant which lacked the ability to produce the patulin pathway metabolites m-cresol, toluquinol, m-hydroxybenzyl-alcohol, m-hydroxybenzaldehyde, gentisaldehyde, gentisyl alcohol, gentisic acid and patulin, as well as the pathway enzyme m-hydroxybenzyl-alcohol dehydrogenase, still produced yields of conidia that were equivalent to or greater than those of the parent strain.
1(0,0,0,1) Details
1981539 Chapman DE, Moore TJ, Michener SR, Powis G: Metabolism and covalent binding of [14C] toluene by human and rat liver microsomal fractions and liver slices. Drug Metab Dispos. 1990 Nov-Dec;18(6):929-36.

Cresols and cresol conjugates were not detected in human or rat liver slice incubations.
These results suggest that cytochrome P-450, rather than alcohol dehydrogenase, was responsible for the metabolism of benzyl alcohol to benzaldehyde.
1(0,0,0,1) Details